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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain the chromosomal alterations seen in cancer cells1. A defectiveExpand
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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Using in vitro gene amplification by the polymerase chain reaction (PCR) and mutation detection by the RNAase A mismatch cleavage method, we have examined c-K-ras genes in human pancreaticExpand
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Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype
Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ colon adenocarcinomas examinedExpand
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Frameshift mutator mutations
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Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We have identified several human tumour cell lines with up to 1,000–foldExpand
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Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.
An exacerbated genomic instability characterizes hereditary and sporadic gastrointestinal cancer of the microsatellite mutator phenotype (MMP), generating somatic frameshift mutations in genesExpand
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Three human transforming genes are related to the viral ras oncogenes.
Three distinct transforming genes present in human tumor cell lines are all related to the viral oncogenes of Harvey and Kirsten murine sarcoma viruses, designated v-H-ras and v-K-ras, respectively.Expand
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Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.
A replication error (RER+) phenotype, characterized by somatic instability in simple repeated sequences, is associated with several types of cancer. To determine if a defect in DNA replicationExpand
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Comparative analysis of mutations in the p53 and K‐ras genes in pancreatic cancer
Mutations in codon 12 of K‐ras occur in a high proportion of pancreatic cancer cases. Although there is evidence that p53 mutations also occur in this tumor, few studies have been reported to dateExpand
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Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer.
An exacerbated genomic instability at simple repeated sequences characterizes cancer of the microsatellite mutator phenotype (MMP). The majority of hereditary nonpolyposis colon cancers (HNPCCs) andExpand
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