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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
TLDR
RANKL selectively induces NFATc1 expression via TRAF6 and c-Fos signaling pathways, and may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL. Expand
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
TLDR
It is demonstrated here that purified, recombinant LIF can substitute for DIA in the maintenance of totipotent ES cell lines that retain the potential to form chimaeric mice. Expand
AP-1: a double-edged sword in tumorigenesis
TLDR
This work focuses on the JUN and FOS proteins and aims to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development. Expand
Signal integration by JNK and p38 MAPK pathways in cancer development
TLDR
This Review highlights the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers. Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed. Expand
A Validated Regulatory Network for Th17 Cell Specification
TLDR
It is found that cooperatively bound BATF and IRF4 contribute to initial chromatin accessibility and, with STAT3, initiate a transcriptional program that is then globally tuned by the lineage-specifying TF RORγt, which plays a focal deterministic role at key loci. Expand
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
TLDR
It is found that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells. Expand
Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon.
TLDR
The results support a model in which separate, lineage-related EGF- and FGF-responsive neural stem cells are present in the embryonic telencephalic germinal zone, and show that EGF alone and F GF2 alone can independently elicit neural stem cell proliferation and at relatively high cell densities separate cell nonautonomous effects can substantially enhance the mitogen-induced proliferation. Expand
Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase
TLDR
The results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis. Expand
Reaching a genetic and molecular understanding of skeletal development.
TLDR
The role of the principal growth factors and transcription factors affecting different processes of skeletal development, chondrogenesis, joint formation, and osteogenesis are addressed and the genetic cascade leading to cell differentiation is presented. Expand
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