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TK1 protein, human
Known as:
EC 2.7.1.21
, TK1
, thymidine kinase 1, soluble protein, human
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Thymidine kinase, cytosolic (234 aa, ~25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.
National Institutes of Health
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Related topics
Related topics
8 relations
Cytoplasmic matrix
Enzyme Gene
Mitotic Cell Cycle
Phosphorylation
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Broader (1)
Thymidine Kinase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Charge dependent substrate activity of C3' and N3 functionalized, organometallic technetium and rhenium-labeled thymidine derivatives toward human thymidine kinase 1.
H. Struthers
,
D. Viertl
,
M. Kosiński
,
B. Spingler
,
F. Buchegger
,
R. Schibli
Bioconjugate chemistry
2010
Corpus ID: 25888884
Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for the noninvasive imaging of cancer cell…
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2004
2004
Biochemical and Structural Characterization of (South)-Methanocarbathymidine That Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-transduced Osteosarcoma Cells*
P. Schelling
,
M. T. Claus
,
Regula Johner
,
V. Marquez
,
G. Schulz
,
L. Scapozza
Journal of Biological Chemistry
2004
Corpus ID: 24517915
Two analogs of the natural nucleoside dT featuring a pseudosugar with fixed conformation in place of the deoxyribosyl residue…
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2002
2002
A Comparative Study: Immunohistochemical Detection of Cytosolic Thymidine Kinase and Proliferating Cell Nuclear Antigen in Breast Cancer
Y. Mao
,
Jianping Wu
,
+4 authors
S. Skog
Cancer Investigation
2002
Corpus ID: 23072666
To explore the expression of cytosolic thymidine kinase 1 (TK1) as a cell proliferative marker in human breast cancers…
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2001
2001
Investigation on Cell Proliferation with a New Antibody against Thymidine Kinase 1
Naining Wang
,
Qimin He
,
S. Skog
,
S. Eriksson
,
B. Tribukait
Analytical Cellular Pathology
2001
Corpus ID: 15896136
The cytosolic thymidine kinase 1 (TK1) is one of the enzymes involved in DNA replication. Based on biochemical studies, TK1 is…
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2001
2001
A monoclonal antibody specific for human thymidine kinase 1.
F. Zhang
,
X. Shao
,
H. Li
,
J. G. Robison
,
B. K. Murray
,
K. O’Neill
Hybridoma
2001
Corpus ID: 37875294
Previous research has shown that thymidine kinase 1 (TK1), a nucleotide salvage pathway enzyme, is an accurate prognostic and…
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2000
2000
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
Jiangping Wu
,
Yomgrong Mao
,
+4 authors
Sven Skog
Anticancer Research
2000
Corpus ID: 25877849
BACKGROUND Proliferation markers are necessary for reliable diagnosis. Here we have presented for the first time thymidine kinase…
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1998
1998
Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals.
B. Jacobsson
,
S. Britton
,
Y. Törnevik
,
S. Eriksson
Biochemical Pharmacology
1998
Corpus ID: 25255330
1995
1995
Different affinity of the two forms of human cytosolic thymidine kinase towards pyrimidine analogs.
B. Munch‐Petersen
,
G. Tyrsted
,
L. Cloos
,
R. Beck
,
K. Eger
Biochimica et Biophysica Acta
1995
Corpus ID: 23776463
1989
1989
Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography.
N. Tamiya
,
Toshikazu Yusa
,
+4 authors
Shinji Fujimura
Biochimica et Biophysica Acta
1989
Corpus ID: 20924185
Highly Cited
1988
Highly Cited
1988
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells.
J L Sherley
,
T J Kelly
Journal of Biological Chemistry
1988
Corpus ID: 42604212
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