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TK1 protein, human

Known as: EC 2.7.1.21, TK1, thymidine kinase 1, soluble protein, human 
Thymidine kinase, cytosolic (234 aa, ~25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.
National Institutes of Health

Related topics

Related topics

8 relations
Cytoplasmic matrixEnzyme GeneMitotic Cell CyclePhosphorylation
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Broader (1)

Thymidine Kinase

Papers overview

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Highly Cited
2008
Highly Cited
2008
"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest.
The site-specific conjugation of metal chelating systems to biologically relevant molecules is an important contemporary topic in… Expand
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Highly Cited
2005
Highly Cited
2005
Structure of a type II thymidine kinase with bound dTTP
The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2′‐deoxythymidine‐5′‐triphosphate was… Expand
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Highly Cited
2004
Highly Cited
2004
Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine… Expand
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Highly Cited
2003
Highly Cited
2003
Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools
Nuclear and mitochondrial (mt) DNA replication occur within two physically separated compartments and on different time scales… Expand
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Highly Cited
2003
Highly Cited
2003
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
The thymidine kinase (Tk) gene codes for a cytosolic protein involved in the pyrimidine nucleotide salvage pathway. A functional… Expand
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Highly Cited
2003
Highly Cited
2003
Production and characterisation of a novel chicken IgY antibody raised against C-terminal peptide from human thymidine kinase 1.
Egg yolk is a good source of highly specific antibodies against mammalian antigens because of the phylogenetic distance between… Expand
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2001
2001
Investigation on Cell Proliferation with a New Antibody against Thymidine Kinase 1
The cytosolic thymidine kinase 1 (TK1) is one of the enzymes involved in DNA replication. Based on biochemical studies, TK1 is… Expand
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Highly Cited
1998
Highly Cited
1998
Unique Metabolism of a Novel Antivirall-Nucleoside Analog, 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil: a Substrate for Both Thymidine Kinase and Deoxycytidine Kinase
ABSTRACT 2′-Fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) is the first l-nucleoside analog with low cytotoxicity discovered… Expand
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Highly Cited
1996
Highly Cited
1996
Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications…
The capacity of recombinant human cytosolic thymidine kinase (TK1) and bovine mitochondrial thymidine kinase (TK2) to… Expand
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Highly Cited
1992
Highly Cited
1992
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Human cells salvage pyrimidine deoxyribonucleosides via 5'-phosphorylation which is also the route of activation of many… Expand
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