TK1 protein, human

Known as: EC 2.7.1.21, TK1, thymidine kinase 1, soluble protein, human 
Thymidine kinase, cytosolic (234 aa, ~25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.
National Institutes of Health

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Cytoplasmic matrixEnzyme GeneMitotic Cell CyclePhosphorylation
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Thymidine Kinase

Papers overview

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2009
2009
Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration.
Thymidine kinase (TK1) is a key enzyme in the salvage pathway of deoxyribonucleotide metabolism, catalyzing the first step in the… (More)
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2008
2008
"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest.
The site-specific conjugation of metal chelating systems to biologically relevant molecules is an important contemporary topic in… (More)
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2004
2004
Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy.
Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine… (More)
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2004
2004
Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.
Two analogs of the natural nucleoside dT featuring a pseudosugar with fixed conformation in place of the deoxyribosyl residue… (More)
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2002
2002
A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer.
To explore the expression of cytosolic thymidine kinase 1 (TK1) as a cell proliferative marker in human breast cancers… (More)
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2000
2000
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
BACKGROUND Proliferation markers are necessary for reliable diagnosis. Here we have presented for the first time thymidine kinase… (More)
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1998
1998
Unique metabolism of a novel antiviral L-nucleoside analog, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil: a substrate for both thymidine kinase and deoxycytidine kinase.
2'-Fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU) is the first L-nucleoside analog with low cytotoxicity discovered to… (More)
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1995
1995
Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer.
Thymidine kinase (TK) is involved in DNA synthesis by the salvage pathway. In this study, thymidine kinase (TK) was determined in… (More)
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1992
1992
The α-subunit of the skeletal muscle sodium channel is encoded proximal to Tk-1 on mouse Chromosome 11
Recent evidence suggests that the human neuromuscular disorders, hyperkalemic periodic paralysis and paramyotonia congenita, are… (More)
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1982
1982
Human thymidine kinase: purification and some properties of the TK1 isoenzyme from placenta
Human thymidine kinase TK1 isoenzyme has been purified 1 800-fold from placenta to a specific activity of 2.9 nmoles/min/mg of… (More)
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