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TK1 protein, human

Known as: EC 2.7.1.21, TK1, thymidine kinase 1, soluble protein, human 
Thymidine kinase, cytosolic (234 aa, ~25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.
National Institutes of Health

Related topics

Related topics

8 relations
Cytoplasmic matrixEnzyme GeneMitotic Cell CyclePhosphorylation

Broader (1)

Thymidine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Charge dependent substrate activity of C3' and N3 functionalized, organometallic technetium and rhenium-labeled thymidine derivatives toward human thymidine kinase 1.
Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for the noninvasive imaging of cancer cell… 
2004
2004
Biochemical and Structural Characterization of (South)-Methanocarbathymidine That Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-transduced Osteosarcoma Cells*
Two analogs of the natural nucleoside dT featuring a pseudosugar with fixed conformation in place of the deoxyribosyl residue… 
2002
2002
A Comparative Study: Immunohistochemical Detection of Cytosolic Thymidine Kinase and Proliferating Cell Nuclear Antigen in Breast Cancer
To explore the expression of cytosolic thymidine kinase 1 (TK1) as a cell proliferative marker in human breast cancers… 
2001
2001
Investigation on Cell Proliferation with a New Antibody against Thymidine Kinase 1
The cytosolic thymidine kinase 1 (TK1) is one of the enzymes involved in DNA replication. Based on biochemical studies, TK1 is… 
2001
2001
A monoclonal antibody specific for human thymidine kinase 1.
Previous research has shown that thymidine kinase 1 (TK1), a nucleotide salvage pathway enzyme, is an accurate prognostic and… 
2000
2000
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
BACKGROUND Proliferation markers are necessary for reliable diagnosis. Here we have presented for the first time thymidine kinase… 
1998
1998
Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals.
1995
1995
Different affinity of the two forms of human cytosolic thymidine kinase towards pyrimidine analogs.
1989
1989
Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography.
Highly Cited
1988
Highly Cited
1988
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells.
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