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TK1 protein, human

Known as: EC 2.7.1.21, TK1, thymidine kinase 1, soluble protein, human 
Thymidine kinase, cytosolic (234 aa, ~25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.
National Institutes of Health

Related topics

Related topics

8 relations
Cytoplasmic matrixEnzyme GeneMitotic Cell CyclePhosphorylation

Broader (1)

Thymidine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Enzymatic Regulation of Cytosolic Thymidine Kinase 1 and Mitochondrial Thymidine Kinase 2: A Mini Review
The central enzyme on the de novo pathway for synthesis of DNA precursors, the deoxyribonucleoside triphosphates, is… 
Highly Cited
2004
Highly Cited
2004
Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine… 
Highly Cited
2003
Highly Cited
2003
Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools
Nuclear and mitochondrial (mt) DNA replication occur within two physically separated compartments and on different time scales… 
Highly Cited
2003
Highly Cited
2003
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
Highly Cited
2003
Highly Cited
2003
Production and characterisation of a novel chicken IgY antibody raised against C-terminal peptide from human thymidine kinase 1.
Highly Cited
1998
Highly Cited
1998
Unique Metabolism of a Novel Antivirall-Nucleoside Analog, 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil: a Substrate for Both Thymidine Kinase and Deoxycytidine Kinase
ABSTRACT 2′-Fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) is the first l-nucleoside analog with low cytotoxicity discovered… 
Highly Cited
1996
Highly Cited
1996
Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications…
The capacity of recombinant human cytosolic thymidine kinase (TK1) and bovine mitochondrial thymidine kinase (TK2) to… 
Highly Cited
1993
Highly Cited
1993
Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties.
Highly Cited
1992
Highly Cited
1992
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Highly Cited
1988
Highly Cited
1988
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells.
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