Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

TK1 protein, human

Known as: EC 2.7.1.21, TK1, thymidine kinase 1, soluble protein, human 
Thymidine kinase, cytosolic (234 aa, ~25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.
National Institutes of Health

Related topics

Related topics

8 relations
Cytoplasmic matrixEnzyme GeneMitotic Cell CyclePhosphorylation
Expand

Broader (1)

Thymidine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest.
The site-specific conjugation of metal chelating systems to biologically relevant molecules is an important contemporary topic in… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
Highly Cited
2005
Highly Cited
2005
Structure of a type II thymidine kinase with bound dTTP
The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2′‐deoxythymidine‐5′‐triphosphate was… Expand
Highly Cited
2003
Highly Cited
2003
Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools
Nuclear and mitochondrial (mt) DNA replication occur within two physically separated compartments and on different time scales… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2003
Highly Cited
2003
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
The thymidine kinase (Tk) gene codes for a cytosolic protein involved in the pyrimidine nucleotide salvage pathway. A functional… Expand
Highly Cited
2003
Highly Cited
2003
Production and characterisation of a novel chicken IgY antibody raised against C-terminal peptide from human thymidine kinase 1.
Egg yolk is a good source of highly specific antibodies against mammalian antigens because of the phylogenetic distance between… Expand
Highly Cited
2002
Highly Cited
2002
Synthesis of a small library of 3-(carboranylalkyl)thymidines and their biological evaluation as substrates for human thymidine kinases 1 and 2.
A small library consisting of two series of thymidine derivatives containing o-carboranylalkyl groups at the N-3 position was… Expand
Highly Cited
1998
Highly Cited
1998
Unique Metabolism of a Novel Antivirall-Nucleoside Analog, 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil: a Substrate for Both Thymidine Kinase and Deoxycytidine Kinase
ABSTRACT 2′-Fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) is the first l-nucleoside analog with low cytotoxicity discovered… Expand
Highly Cited
1996
Highly Cited
1996
Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications…
The capacity of recombinant human cytosolic thymidine kinase (TK1) and bovine mitochondrial thymidine kinase (TK2) to… Expand
Highly Cited
1992
Highly Cited
1992
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Human cells salvage pyrimidine deoxyribonucleosides via 5'-phosphorylation which is also the route of activation of many… Expand
Highly Cited
1988
Highly Cited
1988
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells.
The mammalian cytosolic thymidine kinase is one of a number of enzymes involved in DNA replication whose activities increase… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE