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TK2 protein, human
Known as:
EC 2.7.1.21
, Thymidine Kinase 2
, TK2
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Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2…
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National Institutes of Health
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Related topics
Related topics
8 relations
DNA Replication
Enzyme Gene
Mitochondrial matrix
Phosphorylation
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Broader (1)
Thymidine Kinase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Severe TK2 enzyme activity deficiency in patients with mild forms of myopathy
Y. Cámara
,
L. Carreño-Gago
,
+15 authors
E. García-Arumí
Neurology
2015
Corpus ID: 1355023
Thymidine kinase 2 (TK2) is a mitochondrial enzyme participating in the salvage of deoxyribonucleotides needed for mitochondrial…
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2014
2014
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs.
R. Sun
,
S. Eriksson
,
Liya Wang
Biochemical and Biophysical Research…
2014
Corpus ID: 8025126
2013
2013
Transgene Expression of Drosophila melanogaster Nucleoside Kinase Reverses Mitochondrial Thymidine Kinase 2 Deficiency*♦
S. Krishnan
,
Xiaoshan Zhou
,
João A. Paredes
,
R. Kuiper
,
S. Curbo
,
A. Karlsson
Journal of Biological Chemistry
2013
Corpus ID: 41489900
Background: Thymidine kinase 2 (TK2) deficiency causes severe mitochondrial DNA (mtDNA) depletion due to absence of nucleotides…
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2013
2013
Phosphorylation of Nucleoside-Metallacarborane and Carborane Conjugates by Nucleoside Kinases
Błażej A Wojtczak
,
A. Olejniczak
,
Liya Wang
,
S. Eriksson
,
Z. Leśnikowski
Nucleosides, Nucleotides & Nucleic Acids
2013
Corpus ID: 9331719
A library of purine and pyrimidine nucleosides modified with carborane or metallacarborane boron clusters at different locations…
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2010
2010
Tissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion
L. Wang
,
S. Eriksson
Nucleosides, Nucleotides & Nucleic Acids
2010
Corpus ID: 36477400
Deficiency in thymidine kinase 2 (TK2) activity due to genetic alterations caused tissue specific mitochondrial DNA (mtDNA…
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2005
2005
A computational model of mitochondrial AZT metabolism.
P. Bradshaw
,
Jiaxin Li
,
D. Samuels
Biochemical Journal
2005
Corpus ID: 21201065
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the…
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2004
2004
Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties.
Jayaseharan Johnsamuel
,
N. Lakhi
,
+4 authors
W. Tjarks
Bioorganic & Medicinal Chemistry
2004
Corpus ID: 25514706
2002
2002
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
K. Lotfi
,
E. Månsson
,
C. Peterson
,
S. Eriksson
,
F. Albertioni
Biochemical and Biophysical Research…
2002
Corpus ID: 24697194
2002
2002
Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro.
V. Grégoire
,
J. Rosier
,
+4 authors
P. Scalliet
Radiotherapy and Oncology
2002
Corpus ID: 19849200
1992
1992
Mammalian thymidine kinase 2. Direct photoaffinity labeling with [32P]dTTP of the enzyme from spleen, liver, heart and brain.
O. Jansson
,
C. Bohman
,
B. Munch‐Petersen
,
S. Eriksson
European Journal of Biochemistry
1992
Corpus ID: 38273667
Thymidine kinase 2 (TK2), also called mitochondrial thymidine kinase, is a pyrimidine deoxyribonucleoside kinase expressed in all…
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