TK2 protein, human

Known as: EC 2.7.1.21, Thymidine Kinase 2, TK2 
Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2… (More)
National Institutes of Health

Papers overview

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2008
2008
Fluoropyrimidines like 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-thymine (FMAU) and 3′-deoxy-3′-fluorothymidine (FLT… (More)
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Review
2008
Review
2008
Increased cellular proliferation is an integral part of the cancer phenotype. Several in vitro assays have been developed to… (More)
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2007
2007
Anti-HIV nucleoside therapy can result in mitochondrial toxicity affecting muscles, peripheral nerves, pancreas and adipose… (More)
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2006
2006
Mitochondrial deoxyribonucleic acid depletion syndromes are autosomal recessive disorders characterized by a reduction of the… (More)
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2006
2006
Long-term use of 3'-azido-3'-deoxythymidine (AZT) is associated with various tissue toxicities, including hepatotoxicity and… (More)
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2003
2003
Decreased mitochondrial thymidine kinase (TK2) activity is associated with mitochondrial DNA (mtDNA) depletion and respiratory… (More)
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Highly Cited
2001
Highly Cited
2001
The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is… (More)
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Highly Cited
1999
Highly Cited
1999
Based on amino acid sequence information from purified mitochondrial thymidine kinase (TK2), a cDNA of 1930 bp was cloned… (More)
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1997
1997
Human thymidine kinase 2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine… (More)
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Highly Cited
1991
Highly Cited
1991
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and the mitochondrial, constitutively… (More)
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