TK2 protein, human

Known as: EC 2.7.1.21, Thymidine Kinase 2, TK2 
Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2… (More)
National Institutes of Health

Related topics

Related topics

8 relations
DNA ReplicationEnzyme GeneMitochondrial matrixPhosphorylation
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Broader (1)

Thymidine Kinase

Papers overview

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2008
2008
Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2
Fluoropyrimidines like 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-thymine (FMAU) and 3′-deoxy-3′-fluorothymidine (FLT… (More)
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Review
2008
Review
2008
Imaging of cell proliferation: status and prospects.
Increased cellular proliferation is an integral part of the cancer phenotype. Several in vitro assays have been developed to… (More)
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2007
2007
Expression of deoxynucleoside kinases and 5'-nucleotidases in mouse tissues: implications for mitochondrial toxicity.
Anti-HIV nucleoside therapy can result in mitochondrial toxicity affecting muscles, peripheral nerves, pancreas and adipose… (More)
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2006
2006
New mutations in TK2 gene associated with mitochondrial DNA depletion.
Mitochondrial deoxyribonucleic acid depletion syndromes are autosomal recessive disorders characterized by a reduction of the… (More)
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2006
2006
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
Long-term use of 3'-azido-3'-deoxythymidine (AZT) is associated with various tissue toxicities, including hepatotoxicity and… (More)
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2003
2003
mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency.
Decreased mitochondrial thymidine kinase (TK2) activity is associated with mitochondrial DNA (mtDNA) depletion and respiratory… (More)
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Highly Cited
2001
Highly Cited
2001
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy
The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is… (More)
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Highly Cited
1999
Highly Cited
1999
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.
Based on amino acid sequence information from purified mitochondrial thymidine kinase (TK2), a cDNA of 1930 bp was cloned… (More)
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1997
1997
Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2.
Human thymidine kinase 2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine… (More)
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Highly Cited
1991
Highly Cited
1991
Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides.
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and the mitochondrial, constitutively… (More)
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