Skip to search formSkip to main contentSkip to account menu

TK2 protein, human

Known as: EC 2.7.1.21, Thymidine Kinase 2, TK2 
Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2… 
National Institutes of Health

Related topics

Related topics

8 relations
DNA ReplicationEnzyme GeneMitochondrial matrixPhosphorylation

Broader (1)

Thymidine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Severe TK2 enzyme activity deficiency in patients with mild forms of myopathy
Thymidine kinase 2 (TK2) is a mitochondrial enzyme participating in the salvage of deoxyribonucleotides needed for mitochondrial… 
2014
2014
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs.
2013
2013
Transgene Expression of Drosophila melanogaster Nucleoside Kinase Reverses Mitochondrial Thymidine Kinase 2 Deficiency*♦
Background: Thymidine kinase 2 (TK2) deficiency causes severe mitochondrial DNA (mtDNA) depletion due to absence of nucleotides… 
2013
2013
Phosphorylation of Nucleoside-Metallacarborane and Carborane Conjugates by Nucleoside Kinases
A library of purine and pyrimidine nucleosides modified with carborane or metallacarborane boron clusters at different locations… 
2010
2010
Tissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion
Deficiency in thymidine kinase 2 (TK2) activity due to genetic alterations caused tissue specific mitochondrial DNA (mtDNA… 
2005
2005
A computational model of mitochondrial AZT metabolism.
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the… 
2004
2004
Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties.
2002
2002
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
2002
2002
Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro.
1992
1992
Mammalian thymidine kinase 2. Direct photoaffinity labeling with [32P]dTTP of the enzyme from spleen, liver, heart and brain.
Thymidine kinase 2 (TK2), also called mitochondrial thymidine kinase, is a pyrimidine deoxyribonucleoside kinase expressed in all… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)