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TK2 protein, human

Known as: EC 2.7.1.21, Thymidine Kinase 2, TK2 
Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2… 
National Institutes of Health

Related topics

Related topics

8 relations
DNA ReplicationEnzyme GeneMitochondrial matrixPhosphorylation

Broader (1)

Thymidine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle
This is the second part of a two-part document intended to discuss recent therapeutic progresses in genetic neuromuscular… 
2015
2015
Severe TK2 enzyme activity deficiency in patients with mild forms of myopathy
Thymidine kinase 2 (TK2) is a mitochondrial enzyme participating in the salvage of deoxyribonucleotides needed for mitochondrial… 
2013
2013
Transgene Expression of Drosophila melanogaster Nucleoside Kinase Reverses Mitochondrial Thymidine Kinase 2 Deficiency*♦
Background: Thymidine kinase 2 (TK2) deficiency causes severe mitochondrial DNA (mtDNA) depletion due to absence of nucleotides… 
2011
2011
Deoxynucleoside Salvage Facilitates DNA Repair During Ribonucleotide Reductase Blockade in Human Cervical Cancers
Cells generate 2′-deoxyribonucleoside triphosphates (dNTPs) for both replication and repair of damaged DNA predominantly through… 
Highly Cited
2008
Highly Cited
2008
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice.
Deficient enzymatic activity of the mitochondrial deoxyribonucleoside kinases deoxyguanosine kinase (DGUOK) or thymidine kinase 2… 
2004
2004
Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties.
2002
2002
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
2002
2002
Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro.
Highly Cited
2000
Highly Cited
2000
Mitochondrial and submitochondrial localization of human deoxyguanosine kinase.
Deoxyguanosine kinase and thymidine kinase 2 are responsible for catalysing the first step in the salvage of deoxynucleosides in… 
1991
1991
Expression and substrate specificities of human thymidine kinase 1, thymidine kinase 2 and deoxycytidine kinase.
Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy… 
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