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Thioguanine

Known as: 6 Thioguanine, 2-Aminopurine-6-thiol, 2-Amino-1,7-dihydro-6H-purine-6-thione 
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA… 
National Institutes of Health

Related topics

Related topics

42 relations
6-Thioguanine:EntSub:Pt:RBC:Qn6-Thioguanine:PrThr:Pt:RBC:OrdAcute Basophilic LeukemiaAmidophosphoribosyltransferase

Narrower (14)

6-methylthioguanineBerlin-Frankfurt-Muenster protocol IICT protocolL-6 protocol

Broader (1)

mercaptopurine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1987
Highly Cited
1987
Mutagenicity of 4-hydroxynonenal in V79 Chinese hamster cells.
Highly Cited
1987
Highly Cited
1987
Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests.
Highly Cited
1986
Highly Cited
1986
Analyses of mutation in pSV2gpt-transformed CHO cells.
Highly Cited
1984
Highly Cited
1984
Genetic damage in CHO cells exposed to enzymically generated active oxygen species.
Highly Cited
1984
Highly Cited
1984
Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector.
Highly Cited
1981
Highly Cited
1981
Genomic rearrangements in a mouse cell line containing integrated SV40 DNA
Highly Cited
1981
Highly Cited
1981
High dose chemotherapy and autologous bone marrow transplantation in acute leukemias, malignant lymphomas and solid tumors. A study of 23 patients.
Highly Cited
1977
Highly Cited
1977
Liver homogenate-mediated mutagenesis in chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins.
Highly Cited
1976
Highly Cited
1976
Linear dose--response relationships after prolonged expression times in V-79 Chinese hamster cells.
Highly Cited
1975
Highly Cited
1975
A mutational assay system for L5178Y mouse lymphoma cells, using hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT) -deficiency as marker. The occurrence of a long expression time for mutations…
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