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Thioguanine

Known as: 6 Thioguanine, 2-Aminopurine-6-thiol, 2-Amino-1,7-dihydro-6H-purine-6-thione 
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA… 
National Institutes of Health

Related topics

Related topics

42 relations
6-Thioguanine:EntSub:Pt:RBC:Qn6-Thioguanine:PrThr:Pt:RBC:OrdAcute Basophilic LeukemiaAmidophosphoribosyltransferase

Narrower (14)

6-methylthioguanineBerlin-Frankfurt-Muenster protocol IICT protocolL-6 protocol

Broader (1)

mercaptopurine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1989
Highly Cited
1989
Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells.
Highly Cited
1981
Highly Cited
1981
Comparison of the effects of hydrogen peroxide and x-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79).
Review
1981
Review
1981
The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program.
Highly Cited
1978
Highly Cited
1978
Sister chromatid exchange studies for monitoring DNA damage and repair capacity after cytostatics in vitro and in lymphocytes of leukaemic patients under cytostatic therapy.
  • T. Raposa
  • Mutation research
  • 1978
  • Corpus ID: 24280752
Highly Cited
1977
Highly Cited
1977
A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): development and definition of the system.
Highly Cited
1977
Highly Cited
1977
HIGH REMISSION-INDUCTION RATE IN ACUTE MYELOID LEUKÆMIA
Highly Cited
1977
Highly Cited
1977
Liver homogenate-mediated mutagenesis in chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins.
Highly Cited
1976
Highly Cited
1976
Linear dose--response relationships after prolonged expression times in V-79 Chinese hamster cells.
Highly Cited
1975
Highly Cited
1975
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined in H.Ep. 2 cells grown in culture… 
Highly Cited
1969
Highly Cited
1969
Treatment of adult acute leukemia with arabinosylcytosine and thioguanine
Forty unselected adults with acute leukemia were treated with CA (2–3 mg/kg) by daily rapid intravenous injection and TG (2.5 mg… 
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