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Thioguanine

Known as: 6 Thioguanine, 2-Aminopurine-6-thiol, 2-Amino-1,7-dihydro-6H-purine-6-thione 
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA… 
National Institutes of Health

Related topics

Related topics

42 relations
6-Thioguanine:EntSub:Pt:RBC:Qn6-Thioguanine:PrThr:Pt:RBC:OrdAcute Basophilic LeukemiaAmidophosphoribosyltransferase

Narrower (14)

6-methylthioguanineBerlin-Frankfurt-Muenster protocol IICT protocolL-6 protocol

Broader (1)

mercaptopurine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Neutral carriers based polymeric membrane electrodes for selective determination of mercury (II).
Highly Cited
2005
Highly Cited
2005
Human MutScv recognizes damaged DNA base pairs containing 06-methylguanine, 04-methylthymine, or the cisplatin-d(GpG) adduct
Bacterial and mammalian mismatch repair systems have been implicated in the cellular response to certain types of DNA damage, and… 
Highly Cited
2004
Highly Cited
2004
Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells.
Spermatogonial stem cells (SSCs) self-renew and produce large numbers of committed progenitors that are destined to differentiate… 
Highly Cited
1999
Highly Cited
1999
High incidence of secondary brain tumours after radiotherapy and antimetabolites
Highly Cited
1991
Highly Cited
1991
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia.
Highly Cited
1990
Highly Cited
1990
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
Highly Cited
1987
Highly Cited
1987
Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6‐thioguanine nucleotide concentrations
Thiopurine methyltransferase (TPMT) catalyzes the S‐methylation of thiopurine drugs such as 6‐mercaptopurine (6‐MP) and… 
Highly Cited
1982
Highly Cited
1982
T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.
Rare thioguanine-resistant T lymphocytes, present in vivo in human peripheral blood, were isolated and grown in vitro as… 
Highly Cited
1982
Highly Cited
1982
A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange.
Highly Cited
1975
Highly Cited
1975
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined in H.Ep. 2 cells grown in culture… 
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