Thioguanine

Known as: 6 Thioguanine, 2-Aminopurine-6-thiol, 2-Amino-1,7-dihydro-6H-purine-6-thione 
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Total mercury (THg), methylmercury (MeHg) and 22 other trace elements were measured in ice algae, three species of zooplankton… (More)
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Highly Cited
2004
Highly Cited
2004
Spermatogonial stem cells (SSCs) self-renew and produce large numbers of committed progenitors that are destined to differentiate… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND AND AIM The immunosuppressive properties of 6-mercaptopurine and its parent compound azathioprine are mediated by… (More)
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Highly Cited
1999
Highly Cited
1999
Early intensification of chemotherapy with high-dose cytarabine either in the postremission or remission induction phase has… (More)
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Highly Cited
1998
Highly Cited
1998
6-thioguanine (6-TGN) and methyl 6-mercaptopurine nucleotides (Me6-MPNs) are the two major metabolites found in erythrocytes… (More)
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Highly Cited
1996
Highly Cited
1996
It is proposed here that the delayed cytotoxicity of thioguanine involves the postreplicative DNA mismatch repair system. After… (More)
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Highly Cited
1992
Highly Cited
1992
A reversed-phase high-performance liquid chromatographic assay was developed to quantify intracellular metabolites of the… (More)
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Highly Cited
1991
Highly Cited
1991
Mutant mitochondrial DNA with large-scale deletions (delta-mtDNA) has been frequently observed in patients with chronic… (More)
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Highly Cited
1987
Highly Cited
1987
We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem… (More)
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Highly Cited
1987
Highly Cited
1987
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and… (More)
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