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The wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts.
- I. C. Enninga, R. Groenendijk, A. Filon, A. V. van Zeeland, J. Simons
- Biology, Medicine
- Carcinogenesis
- 1 November 1986
In this study, we determined the wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts. Pyrimidine dimers were… Expand
Biochemical properties of staphylococcal (phospho)lipases.
- J. Simons, F. Götz, M. Egmond, H. Verheij
- Chemistry, Medicine
- Chemistry and physics of lipids
- 1 June 1998
Various staphylococci secrete lipases which require calcium ions for activity, and have profound preferences for substrates with different chain lengths. The lipase from Staphylococcus hyicus is… Expand
Mutagen-sensitive cell lines are obtained with a high frequency in V79 Chinese hamster cells.
- M. Zdzienicka, J. Simons
- Medicine
- Mutation research
- 1987
A replica-plating technique has been adopted for the isolation of mutagen-sensitive mutants of Chinese hamster V79 and CHO cell lines. After the mutagenic treatment (ENU) clones derived from these… Expand
DNA strand specificity for UV-induced mutations in mammalian cells.
- H. Vrieling, M. van Rooijen, +4 authors A. V. van Zeeland
- Biology, Medicine
- Molecular and cellular biology
- 1 March 1989
The influence of DNA repair on the molecular nature of mutations induced by UV light (254 nm) was investigated in UV-induced hprt mutants from UV-sensitive Chinese hamster cells (V-H1) and the… Expand
The Chinese hamster V79 cell mutant V-H4 is phenotypically like Fanconi anemia cells
- M. Z. Zdzienicka, F. Arwert, I. Neuteboom, M. Rooimans, J. Simons
- Biology, Medicine
- Somatic cell and molecular genetics
- 1 November 1990
It has been shown by genetic complementation analysis that a mitomycin C-sensitive mutant (V-H4) of Chinese hamster V79 cells is the first rodent equivalent of Fanconi anemia (FA) group A. The V-H4… Expand
Multimethodische Bewertung von Schweinehaltungsverfahren durch Verbraucher anhand von Videos aus realen Schweineställen
- Christiane Wildraut, Gudrun Plesch, +4 authors M. Hartmann
- Geography
- 2015
- 10
- 2
Linear dose--response relationships after prolonged expression times in V-79 Chinese hamster cells.
- A. V. van Zeeland, J. Simons
- Biology, Medicine
- Mutation research
- 1 April 1976
The expression time for induced mutants resistant to 6-thioguanine, in V-79 Chinese hamster cells, was determined by respreading the cells in the selective medium, at various times after treatment.… Expand
Development of a liquid-holding technique for the study of DNA-repair in human diploid fibroblasts.
- J. Simons
- Biology, Medicine
- Mutation research
- 1 February 1979
Liquid-holding conditions can be obtained for human diploid skin fibroblasts by keeping confluent cultures stationary over periods of 7 days or longer by means of conditioned medium. Under this… Expand
Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene.
- H. Vrieling, J. Venema, +6 authors A. V. van Zeeland
- Biology, Medicine
- Nucleic acids research
- 11 May 1991
DNA excision repair modulates the mutagenic effect of many genotoxic agents. The recently observed strand specificity for removal of UV-induced cyclobutane dimers from actively transcribed genes in… Expand
Analysis of repair processes by the determination of the induction of cell killing and mutations in two repair-deficient Chinese hamster ovary cell lines.
- M. Zdzienicka, J. Simons
- Biology, Medicine
- Mutation research
- 1 July 1986
Two UV sensitive DNA-repair-deficient mutants of Chinese hamster ovary cells (43-3B and 27-1) have been characterized. The sensitivity of these mutants to a broad spectrum of DNA-damaging agents:… Expand