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The wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts.
In this study, we determined the wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts. Pyrimidine dimers wereExpand
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Biochemical properties of staphylococcal (phospho)lipases.
Various staphylococci secrete lipases which require calcium ions for activity, and have profound preferences for substrates with different chain lengths. The lipase from Staphylococcus hyicus isExpand
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Mutagen-sensitive cell lines are obtained with a high frequency in V79 Chinese hamster cells.
A replica-plating technique has been adopted for the isolation of mutagen-sensitive mutants of Chinese hamster V79 and CHO cell lines. After the mutagenic treatment (ENU) clones derived from theseExpand
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DNA strand specificity for UV-induced mutations in mammalian cells.
The influence of DNA repair on the molecular nature of mutations induced by UV light (254 nm) was investigated in UV-induced hprt mutants from UV-sensitive Chinese hamster cells (V-H1) and theExpand
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The Chinese hamster V79 cell mutant V-H4 is phenotypically like Fanconi anemia cells
It has been shown by genetic complementation analysis that a mitomycin C-sensitive mutant (V-H4) of Chinese hamster V79 cells is the first rodent equivalent of Fanconi anemia (FA) group A. The V-H4Expand
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Linear dose--response relationships after prolonged expression times in V-79 Chinese hamster cells.
The expression time for induced mutants resistant to 6-thioguanine, in V-79 Chinese hamster cells, was determined by respreading the cells in the selective medium, at various times after treatment.Expand
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Development of a liquid-holding technique for the study of DNA-repair in human diploid fibroblasts.
  • J. Simons
  • Biology, Medicine
  • Mutation research
  • 1 February 1979
Liquid-holding conditions can be obtained for human diploid skin fibroblasts by keeping confluent cultures stationary over periods of 7 days or longer by means of conditioned medium. Under thisExpand
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Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene.
DNA excision repair modulates the mutagenic effect of many genotoxic agents. The recently observed strand specificity for removal of UV-induced cyclobutane dimers from actively transcribed genes inExpand
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Analysis of repair processes by the determination of the induction of cell killing and mutations in two repair-deficient Chinese hamster ovary cell lines.
Two UV sensitive DNA-repair-deficient mutants of Chinese hamster ovary cells (43-3B and 27-1) have been characterized. The sensitivity of these mutants to a broad spectrum of DNA-damaging agents:Expand
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