mercaptopurine

Known as: 6H-Purine-6-thione, 1,7-dihydro- (9CI), Mercaptopurina, MP 
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
BACKGROUND Inflammatory bowel disease (IBD) is commonly treated with immunomodulators such as azathioprine and 6-mercaptopurine… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
CONTEXT Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Conventional therapy for childhood acute lymphoblastic leukemia (ALL) includes prednisone and oral 6-mercaptopurine. Prior… (More)
  • figure 1
  • table 1
  • table 2
  • table 2
  • figure 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
BACKGROUND Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine, and those with homozygous… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
6-Mercaptopurine (6MP) and methotrexate are the backbone of continuation therapy for childhood acute lymphoblastic leukemia (ALL… (More)
  • table 1
  • figure 2
  • figure 3
  • figure 4
  • table 2
Is this relevant?
Review
1997
Review
1997
Advances in the molecular and immunologic characterization of leukemic cells have greatly aided the diagnosis and risk assignment… (More)
Is this relevant?
Review
1992
Review
1992
The cytotoxic drug 6-mercaptopurine (6-MR b-thiopurine) and the closely related immunosuppressive agent azathioprine (6-(1-methyl… (More)
  • figure 3
Is this relevant?
Highly Cited
1989
Highly Cited
1989
We assess toxicity related to 6-mercaptopurine in the treatment of inflammatory bowel disease by reporting our experience with… (More)
Is this relevant?
Highly Cited
1980
Highly Cited
1980
To test the effectiveness of 6-mercaptopurine (6-MP) in the treatment of Crohn's disease, we entered 83 chronically ill patients… (More)
Is this relevant?