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mercaptopurine

Known as: 6H-Purine-6-thione, 1,7-dihydro- (9CI), Mercaptopurina, MP 
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by… 
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (23)

(9H-purin-6-yl)thiomethyl glutamate2-piperidino-8-mercaptoadenine6-Mercaptopurine Monohydrate6-carboxymethylthiopurine
DNA Synthesis InhibitionHepatic Metabolism [PK]In BloodIntestinal Metabolism [PK]

Broader (2)

Immunosuppressive Agentsthiopurine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Meta‐analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis
Background  Debate exists regarding to whether thiopurine therapy is as effective in ulcerative colitis (UC) as it is in Crohn's… 
Highly Cited
2005
Highly Cited
2005
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
CONTEXT Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an… 
Highly Cited
2004
Highly Cited
2004
Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands
Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in… 
Review
2001
Review
2001
The treatment of inflammatory bowel disease with 6‐mercaptopurine or azathioprine
The thioguanine derivative, azathioprine, is a prodrug of 6‐mercaptopurine that is further metabolized by various enzymes present… 
Highly Cited
1998
Highly Cited
1998
Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia–implications for treatment of infants
The prognosis of infant ALL, characterized by a high incidence of the immature CD10 negative B-lineage ALL (proB ALL) is poor… 
Highly Cited
1989
Highly Cited
1989
6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity.
We assess toxicity related to 6-mercaptopurine in the treatment of inflammatory bowel disease by reporting our experience with… 
Highly Cited
1981
Highly Cited
1981
Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.
The metastatic stability of clones, which were derived from the murine UV-2237 fibrosarcoma and which exhibit low or high… 
Highly Cited
1975
Highly Cited
1975
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined in H.Ep. 2 cells grown in culture… 
Highly Cited
1974
Highly Cited
1974
A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.
6-Thioguanosine-35S and β-2′-deoxythioguanosine-35S were identified in venom hydrolysates of RNA and DNA isolated from 6… 
Highly Cited
1965
Highly Cited
1965
The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia.
1. Combinations of effective agents produce at least an additive increase in complete remission rates over that which can be… 
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