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mercaptopurine
Known as:
6H-Purine-6-thione, 1,7-dihydro- (9CI)
, Mercaptopurina
, MP
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A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by…
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National Institutes of Health
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Related topics
Related topics
48 relations
Narrower (23)
(9H-purin-6-yl)thiomethyl glutamate
2-piperidino-8-mercaptoadenine
6-Mercaptopurine Monohydrate
6-carboxymethylthiopurine
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DNA Synthesis Inhibition
Hepatic Metabolism [PK]
In Blood
Intestinal Metabolism [PK]
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Broader (2)
Immunosuppressive Agents
thiopurine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1973
1973
Failure of combined factor VIII and cyclophosphamide to suppress antibody to factor VIII in hemophilia.
M. Hruby
,
Irving Schulman
Blood
1973
Corpus ID: 13331469
Two patients with hemophilia A and antifactor VIII antibodies were treated with infusions of factor VIII concentrates and…
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1972
1972
Synergistic effect of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside on the levels of adenine nucleotides of Sarcoma 180 cells.
E. Scholar
,
Phyllis R. Brown
,
Robert E. Parks
Cancer Research
1972
Corpus ID: 7429120
Summary The synergistic antitumor action of 6-mercaptopurine (6-MP) and 6-methylmercaptopurine ribonucleoside (MMPR) is confirmed…
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1971
1971
Is azathioprine a better immunosuppressive than 6-mercaptopurine?
M. Berenbaum
Clinical and Experimental Immunology
1971
Corpus ID: 24625662
The toxicities and immunosuppressive potencies of single doses of 6-mercaptopurine and azathioprine have been compared in mice…
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1969
1969
Retention of 6-mercaptopurine derivatives by intact cells as an index of drug response in human and murine leukemias.
David Kessel
,
Thomas C. Hall
Cancer Research
1969
Corpus ID: 9145843
Human and animal leukemias, varying widely in responsiveness to 6-mercaptopurine, were examined to seek determinants of drug…
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Highly Cited
1965
Highly Cited
1965
INHIBITION OF PRUINE PHOSPHORIBOSYLTRANSFERASES OF EHRLICH ASCITES-TUMOUR CELLS BY 6-MERCAPTOPURINE.
M. R. Atkinson
,
Andrew W. Murray
Biochemical Journal
1965
Corpus ID: 20573216
1. The formation of adenosine 5'-phosphate, guanosine 5'-phosphate and inosine 5'-phosphate from [8-(14)C]adenine, [8-(14)C…
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1961
1961
The Incorporation of 6-Mercaptopurine-S35 into the Nucleic Acids of Sensitive and Nonsensitive Transplantable Mouse Tumors
S. Bieber
,
L. Dietrich
,
G. Elion
,
G. Hitchings
,
D. Martin
1961
Corpus ID: 82146013
Summary The incorporation of 6-mercaptopurine-S35 into the deoxyribonucleic acids of several mouse tumors has been studied, with…
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Highly Cited
1960
Highly Cited
1960
A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms.
R. Brockman
Cancer Research
1960
Corpus ID: 2670440
Summary Leukemia L1210 ascites tumor cells sensitive to inhibition by 6-mercaptopurine were observed to metabolize hypoxanthine-8…
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Highly Cited
1960
Highly Cited
1960
Studies on the mechanism of action of 6-mercaptopurine in sensitive and resistant L1210 leukemia in vitro.
Jack D. Davidson
Cancer Research
1960
Corpus ID: 29257790
Summary A study was made of the effects of 6-mercaptopurine (6-MP) upon nucleic acid metabolism in L1210 leukemia cells in vitro…
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1958
1958
Metabolism of resistant mutants of Streptococcus faecalis. III. The action of 6-mercaptopurine.
M. Baliś
,
V. Hylin
,
M. Coultas
,
D. Hutchinson
Cancer Research
1958
Corpus ID: 42050991
The effect of 6-mercaptopurine of S. faecalis (ATCC No. 8043) and several of its mutants has been investigated. Some mutants are…
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1956
1956
The influence of azaserine and 6-mercaptopurine on the in vivo metabolism of ascites tumor cells.
J. Fernandes
,
G. A. Lepage
,
A. Lindner
Cancer Research
1956
Corpus ID: 7152714
Several chemical agents are now available which have shown activity in inhibiting or destroying certain experimental cancers…
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