Hepatic Metabolism [PK]

Known as: Hepatic Metabolism, liver metabolism, metabolism liver 
 
National Institutes of Health

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4 ML Diazepam 5 MG/ML Rectal GelAcetaminophen 100 MG/ML Oral SuspensionAcetaminophen 32 MG/ML Oral SuspensionAcetaminophen 325 MG Oral Tablet
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Papers overview

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Highly Cited
2016
Highly Cited
2016
Systems proteomics of liver mitochondria function
Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition of all Theoretical Mass… (More)
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Highly Cited
2012
Highly Cited
2012
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty… (More)
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Highly Cited
2011
Highly Cited
2011
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.
Regulation of hepatic carbohydrate homeostasis is crucial for maintaining energy balance in the face of fluctuating nutrient… (More)
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Review
2010
Review
2010
Fructose: metabolic, hedonic, and societal parallels with ethanol.
Rates of fructose consumption continue to rise nationwide and have been linked to rising rates of obesity, type 2 diabetes, and… (More)
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Highly Cited
2010
Highly Cited
2010
Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events.
UNLABELLED Reactive metabolites generated by hepatic metabolism are thought to play an important role in the pathogenesis of drug… (More)
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Review
2009
Review
2009
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.
As the liver is central in the maintenance of glucose homeostasis and energy storage, knowledge of the physiology as well as… (More)
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Highly Cited
2007
Highly Cited
2007
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
Type 2 diabetes mellitus, a disease with significant effects on the health and economy of Western societies, involves… (More)
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Highly Cited
2005
Highly Cited
2005
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.
Hepatic insulin resistance is a critical component in the development of type 2 diabetes mellitus. In many cases, insulin… (More)
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Highly Cited
2005
Highly Cited
2005
Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.
VELCADE (bortezomib, PS-341), reversibly inhibits the 20S proteasome and exhibits cytotoxic and antitumor activities… (More)
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Highly Cited
1992
Highly Cited
1992
Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel.
The thienopyridine clopidogrel is not active in vitro and must be administered i.v. or orally, suggesting that metabolism is… (More)
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