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Colorimetric Estimation of Succinic Dehydrogenase by Triphenyltetrazolium Chloride.
Molecular interactions between poly(ADP‐ribose) polymerase (PARP I) and topoisomerase I (Topo I): identification of topology of binding
Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds
It is shown that two such compounds, 3-nitrosobenzamide and 6-Nitroso-l,2-benzopyrone, inhibit infection of human immunodeficiency virus HIV- 1 in human lymphocytes and also eject zinc from isolated HIV-1 nucleocapsid zinc fingers and from intact HIV-2 virions.
Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture.
- E. Kun
Enzyme and Metabolic InhibitorsBy J. Leyden Webb. Vol. 2: Malonate, Analogs, Dehydroacetate, Sulfhydryl, 0-Iodosobenzoate, Mercurials. Pp. xx + 1237. 272s. Vol.3: Iodoacetate, Maleate. N…
Regulation of the enzymatic catalysis of poly(ADP-ribose) polymerase by dsDNA, polyamines, Mg2+, Ca2+, histones H1 and H3, and ATP.
A novel regulation of PARP-1 activity and its chromatin-related functions by cellular bioenergetics is proposed that occurs in functional cells not exposed to catastrophic DNA damage.
Probable helical conformation of poly(ADP-ribose). The effect of cations on spectral properties.
The interaction of adenosine diphosphoribosyl transferase (ADPRT) with a cruciform DNA.
Macromolecular enzymatic product of NAD+ in liver mitochondria.
- E. Kun, P. Zimber, A. C. Chang, B. Puschendorf, H. Grunicke
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 April 1975
Rat liver mitochondria contain a Mg2+-requiring system that transfers the ADP-ribose moiety of NAD+ to an acceptor protein, and identification of these products and reversibility of the reaction show that theADP- Ribosylated protein is the molecular species that is transferred to the acceptorprotein.
Studies on the Ehrlich ascites tumor. I. The enzymic and metabolic activities of the ascitic cells and the ascitic plasma.
The activity of a number of enzymes in homogenates of the tumor cells was studied, and mitochondria isolated from such preparations were shown to catalyze a marked uptake of inorganic phosphate concomitant with the oxidation of succinate.