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Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan
TLDR
Data is reviewed on the human exposure, environmental fate, efficacy of anti-microbial activity, absorption, distribution, metabolism and elimination, endocrine disrupting effects, and toxicity of triclosan. Expand
Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles.
TLDR
Recent toxicity and exposure data, combined with therapeutic and other related literature, are beginning to shape risk assessments that will be used to regulate the use of nanomaterials in consumer products. Expand
Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice.
TLDR
Fumonisin B1 is a rodent carcinogen that induces renal tubule tumors in male F344 rats and hepatic tumors in female B6C3F1 mice. Expand
An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.
TLDR
Microscopic and other findings suggest that an imbalance between cell loss and replacement develops, a condition favorable for carcinogenesis, and on the molecular level, fumonisins inhibit ceramide synthase, and disrupt sphingolipid metabolism and, theoretically, sphingoipid-mediated regulatory processes that influence apoptosis and mitosis. Expand
Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells.
TLDR
It is suggested that surface functionalization of SWCNTs decreases ROS-mediated toxicological response in vitro, and alteration of the genes is also surface coating-dependent with a good correlation with the biochemical data. Expand
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example.
TLDR
Fumonisin B(1) may be the first example of an apparently nongenotoxic (non-DNA reactive) agent producing tumors through a mode of action involving apoptotic necrosis, atrophy, and consequent regeneration. Expand
Migration of intradermally injected quantum dots to sentinel organs in mice.
TLDR
Quantification of cadmium and selenium levels after 0, 4, 8, 12, or 24 h in multiple tissues, using inductively coupled plasma mass spectrometry (ICP-MS), showed a time-dependent loss of Cadmium from the injection site, and accumulation in the liver, regional draining lymph nodes, kidney, spleen, and hepatic lymph node. Expand
The safety and regulation of natural products used as foods and food ingredients.
TLDR
This review addresses the safety assessment and regulation of food products containing these substances by the U.S. Food and Drug Administration and addresses the FDA experience in analyzing the safety of natural ingredients described in pre-market safety submissions. Expand
Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin.
TLDR
The results suggest that transdermal absorption of nanoscale materials depends on skin barrier quality, and that the lack of an epidermis provided access to QD penetration. Expand
Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice.
TLDR
Results suggest that, of the naturally occurring fumonisins,fumonisin B(1) is the principal hepatotoxic derivative in the B6C3F(1), and the other fumoniain derivatives did not alter serum analytes, organ weights, or hepatic structure. Expand
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