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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.
BACKGROUND Treatment with peginterferon alfa-2a alone produces significantly higher sustained virologic responses than treatment with interferon alfa-2a alone in patients with chronic hepatitis CExpand
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Sorafenib in advanced hepatocellular carcinoma.
BACKGROUND No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascularExpand
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Functional significance of cell volume regulatory mechanisms.
To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specificallyExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoringExpand
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules,Expand
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Long-term survival in patients with hereditary hemochromatosis.
BACKGROUND & AIMS The course of hereditary hemochromatosis may depend on the degree of iron overload and the time of therapeutic intervention. This analysis evaluates the impact of early diagnosisExpand
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Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa-2a (40 KD)/ribavirin.
BACKGROUND/AIMS Prediction of sustained virological response (SVR) during treatment would allow clinicians to identify patients most likely to benefit from therapy. METHODS Retrospective analysisExpand
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The role of cellular hydration in the regulation of cell function.
  • D. Häussinger
  • Chemistry, Medicine
  • The Biochemical journal
  • 1 February 1996
The cellular hydration state is dynamic and changes within minutes under the influence of aniso-osmolarity, hormones, nutrients and oxidative stress. This occurs despite the activity of potentExpand
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Critical flicker frequency for quantification of low‐grade hepatic encephalopathy
Subclinical hepatic encephalopathy (SHE) is currently diagnosed by psychometric tests or neurophysiologic techniques. In view of its sociomedical relevance, simple and reproducible tests for routineExpand
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IFN‐α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling‐3
Eighty percent of patients newly infected with the hepatitis C virus (HCV) develop chronic infection, suggesting that HCV can develop effective strategies to escape the unspecific and specific immuneExpand
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