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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.
In patients with chronic hepatitis C, once-weekly peginterferon alfa-2a plus ribavirin was tolerated as well as interferonAlfa- 2b plus Ribavirin and produced significant improvements in the rate of sustained virologic response, as compared with interfer on alfa -2b plus ribvirin or pegin terferonalfa-3a alone.
Sorafenib in advanced hepatocellular carcinoma.
In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Functional significance of cell volume regulatory mechanisms.
Cell volume may be considered a second message in the transmission of hormonal signals, and alterations of cell volume and volume regulatory mechanisms participate in a wide variety of cellular functions including epithelial transport, metabolism, excitation, hormone release, migration, cell proliferation, and cell death.
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,…
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Long-term survival in patients with hereditary hemochromatosis.
- C. Niederau, R. Fischer, A. Pürschel, W. Stremmel, D. Häussinger, G. Strohmeyer
- 1 April 1996
Prognosis of hemochromatosis and most of its complications, including liver cancer, depend on the amount and duration of iron excess, and early diagnosis and therapy largely prevent the adverse consequences of iron overload.
The role of cellular hydration in the regulation of cell function.
- D. Häussinger
- BiologyThe Biochemical journal
- 1 February 1996
Cell volume homeostasis does not simply mean volume constancy, but rather the integration of events which allow cell hydration to play its physiological role as a regulator of cell function (for reviews see [1–4]).
Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa-2a (40 KD)/ribavirin.
Critical flicker frequency for quantification of low‐grade hepatic encephalopathy
- G. Kircheis, M. Wettstein, L. Timmermann, A. Schnitzler, D. Häussinger
- Medicine, PsychologyHepatology
- 1 February 2002
CFF is a sensitive, simple, and reliable parameter for quantification of low‐grade HE severity in cirrhotic patients and may be useful for the detection and monitoring of SHE.