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thiopurine

Known as: thiopurines 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Purine NucleosidesSulfur Compoundspurine analog

Narrower (1)

mercaptopurine

Papers overview

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2007
2007
Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia
Dear Editor,Methotrexate (MTX) inhibits several enzymes in folatemetabolic pathway, including dihydrofolate reductase,thymidylate… 
Review
2006
Review
2006
Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase
1. Pharmacogenomics is the study of the role of inheritance in variation in the drug response phenotype—a phenotype that can vary… 
Highly Cited
2005
Highly Cited
2005
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population.
Highly Cited
2005
Highly Cited
2005
A randomized trial of nicotine enemas for active ulcerative colitis.
Highly Cited
2003
Highly Cited
2003
Pharmacoeconomic analysis of thiopurine methyltransferase polymorphism screening by polymerase chain reaction for treatment with azathioprine in Korea.
OBJECTIVES To evaluate the value of genotype-based dosing by polymerase chain reaction (PCR)-based polymorphism screening in… 
Highly Cited
2002
Highly Cited
2002
Thiopurine Methyltransferase Polymorphisms in a Multiracial Asian Population and Children With Acute Lymphoblastic Leukemia
The purpose of this study was to determine the frequency of thiopurine methyltransferase (TPMT) polymorphisms in a multiracial… 
Highly Cited
2001
Highly Cited
2001
Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese.
Polymorphisms at three loci in the thiopurine methyltransferase (TPMT) gene are known to be responsible for azathioprine and 6… 
Highly Cited
2001
Highly Cited
2001
Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity
The genetic polymorphism of thiopurine methyltransferase (TPMT) activity has a significant relevance in the clinical outcome of… 
Highly Cited
1987
Highly Cited
1987
Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells.
1965
1965
INHIBITION OF FORMYLGLYCINAMIDE RIBONUCLEOTIDE SYNTHESIS IN NEOPLASTIC CELLS BY PURINES AND ANALOGS.
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