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Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
- H. Lachman, D. Papolos, T. Saito, Y. M. Yu, C. Szumlanski, R. Weinshilboum
- Biology, PsychologyPharmacogenetics
- 1 June 1996
The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.
- Yan Jin, Z. Desta, D. Flockhart
- Medicine, BiologyJournal of the National Cancer Institute
- 5 January 2005
Interactions between CYP2D6 polymorphisms and coadministered antidepressants and other drugs that are CYP 2D6 inhibitors may be associated with altered tamoxifen activity.
Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.
The segregation of RBC TPMT activity among 215 first-degree relatives in 50 randomly selected families and among 35 members of two kindreds and one family selected because they included probands with undetectable RBC enzyme activity were also compatible with the autosomal codominant inheritance of RBNT.
Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype.
- R. Raftogianis, T. C. Wood, D. Otterness, J. van Loon, R. Weinshilboum
- BiologyBiochemical and biophysical research…
- 9 October 1997
Common SULT1A1 nucleotide polymorphisms that are associated with phenotypic variation in both platelet TS PST activity and thermal stability are reported, step toward understanding molecular mechanisms responsible for the genetic regulation of PSTs in humans.
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily.
- R. Blanchard, R. Freimuth, J. Buck, R. Weinshilboum, M. Coughtrie
- 1 March 2004
It is hoped that this nomenclature system will be widely adopted and that, as novel SULTs are identified and characterized, investigators will name their discoveries according to these guidelines.
Sulfotransferase molecular biology: cDNAs and genes
- R. Weinshilboum, D. Otterness, I. Aksoy, T. C. Wood, C. Her, R. Raftogianis
- BiologyFASEB journal : official publication of the…
- 1 January 1997
Knowledge of the mo‐lecular biology of cytosolic ST enzymes, when placed within a context provided by decades of biochemical research, promises to significantly enhance the authors' understanding of the regulation of the sulfate conjugation of hormones, neurotransmitters, and drugs.
Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects.
It is found that SULT1A1*2 and Sult1A2*2, the most common variant alleles for these two genes, were in positive linkage disequilibrium in all three populations studied, with D' values of 0.776 in Caucasian, 0.915 in Chinese and 0.864 in African-American subjects.
Inheritance and drug response.
- R. Weinshilboum
- Biology, MedicineThe New England journal of medicine
- 6 February 2003
The underlying message is that inherited variations in drug effect are common and that some tests that incorporate pharmacogenetics into clinical practice are now available, with many more to follow.