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Amidophosphoribosyltransferase

Known as: ATase, Phosphoribosyl Pyrophosphate Amidotransferase, Amidophosphoribosyltransferase [Chemical/Ingredient] 
An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formation of 5-phosphoribosylamine from glutamine and… Expand
National Institutes of Health

Related topics

Related topics

19 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GeneGout
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Narrower (1)

Prat2 protein, Drosophila

Broader (1)

pentosyltransferase

Papers overview

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Review
2018
Review
2018
Nrf2 at the heart of oxidative stress and cardiac protection.
The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the expression of antioxidant and detoxification… Expand
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Highly Cited
2006
Highly Cited
2006
Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de novo synthesis of triacylglycerol. It has… Expand
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Review
2003
Review
2003
Variability and regulation of O6-alkylguanine-DNA alkyltransferase.
O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of… Expand
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Review
2001
Review
2001
Channeling of substrates and intermediates in enzyme-catalyzed reactions.
The three-dimensional structures of tryptophan synthase, carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate… Expand
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Highly Cited
1999
Highly Cited
1999
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.
Asparagine synthetase B catalyzes the assembly of asparagine from aspartate, Mg(2+)ATP, and glutamine. Here, we describe the… Expand
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Highly Cited
1997
Highly Cited
1997
hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents
Loss of expression of the hMLH1 and hPMS2 subunits of the MutLα-mismatch repair complex is a frequent event (9/10) in independent… Expand
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Highly Cited
1997
Highly Cited
1997
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Activation of gluatmine phosphoribosylpyrophosphate (RPPP) amidotransferase (GPATase) by binding of a PRPP substrate analog… Expand
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Highly Cited
1995
Highly Cited
1995
A protein catalytic framework with an N-terminal nucleophile is capable of self-activation
THE crystal structures of three amidohydrolases have been determined recently1–3: glutamine PRPP amidotransferase (GAT… Expand
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Highly Cited
1975
Highly Cited
1975
IMP dehydrogenase, an enzyme linked with proliferation and malignancy
PREVIOUS studies conducted in this laboratory demonstrated that in a spectrum of liver tumours with different growth rates there… Expand
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Highly Cited
1975
Highly Cited
1975
Malignant transformation‐linked imbalance: Decreased xanthine oxidase activity in hepatomas
Xanthine oxidase was decreased 2- to 10-fold in all examined rat hepatomas irrespective of the malignancy; growth rate and… Expand
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