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Crypt stem cells as the cells-of-origin of intestinal cancer
Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a previously… Expand
Requirement for a functional Rb-1 gene in murine development
HUMAN retinoblastomas can occur both as hereditary and as sporadic cases. Knudson's proposal1 that they result from two mutational events, of which one is present in the germ line in hereditary… Expand
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
We show that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin, which perturbs differentiation, migration, proliferation, and apoptosis. Expand
Thymocyte apoptosis induced by p53-dependent and independent pathways
DEATH by apoptosis is characteristic of cells undergoing deletion during embryonic development, T- and B-cell maturation and endocrine-induced atrophy1. Apoptosis can be initiated by various… Expand
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+… Expand
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+… Expand
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.
Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At the onset of involution, Stat3 is specifically activated. To address the function of this signaling… Expand
Myc deletion rescues Apc deficiency in the small intestine
The APC gene encodes the adenomatous polyposis coli tumour suppressor protein, germline mutation of which characterizes familial adenomatous polyposis (FAP), an autosomal intestinal cancer syndrome.… Expand
High-frequency developmental abnormalities in p53-deficient mice
BACKGROUND Several strains of mice carrying null mutations of the tumour suppressor gene p53 have been developed. It has been reported that homozygous mice from all of these strains develop normally… Expand
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.
BACKGROUND & AIMS A system for introducing specific gene mutations into the epithelia of the adult murine gastrointestinal tract by the transcriptional regulation of Cre recombinase is presented and… Expand