A. Clarke

Publications234
h-index68
Citations21,347
Highly Influential Citations743
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Crypt stem cells as the cells-of-origin of intestinal cancer
TLDR
It is concluded that stem-cell-specific loss of Apc results in progressively growing neoplasia in long-lived intestinal stem cells.
View on Nature
Requirement for a functional Rb-1 gene in murine development
TLDR
It is reported here that young heterozygous mice do not appear abnormal and do not develop retinoblastoma at a detectable frequency, however, homozygous mutant embryos fail to reach term and show a number of abnormalities in neural and haematopoietic development.
View on Nature
Thymocyte apoptosis induced by p53-dependent and independent pathways
TLDR
The results show that p53 exerts a significant and dose-dependent effect in the initiation of apoptosis, but only when it is induced by agents that cause DNA-strand breakage.
View on Nature
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
TLDR
It is shown that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin, which perturbs differentiation, migration, proliferation, and apoptosis, such that Apc-deficient cells maintain a "crypt progenitor-like" phenotype.
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Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+…
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Myc deletion rescues Apc deficiency in the small intestine
TLDR
Loss of Myc rescued the phenotypes of perturbed differentiation, migration, proliferation and apoptosis, which occur on deletion of Apc, and Array analysis revealed that Myc is required for the majority of Wnt target gene activation following Apc loss.
View on Nature
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+…
View on PubMed
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.
TLDR
It is suggested that IGFBP-5 is a direct or indirect target for Stat3 and its upregulation is essential to normal involution, and the importance of a Stat factor in signaling the initiation of physiological apoptosis in vivo is demonstrated.
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129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
TLDR
The use of a different targeting strategy is reported, to produce inbred mice with a complete absence of both PrP protein and mRNA sequences, which are being used in experiments designed to address the role of PrP in the pathogenesis of scrapie and the replication of infectivity.
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Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.
TLDR
It has been used here to show that beta-catenin is required for the maintenance of intestinal cell proliferation and is implicated in goblet cell differentiation and enterocyte-matrix attachment.
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