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Thapsigargin

Known as: Octanoic Acid, 6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2-methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)azuleno(4,5-b)furan-7-yl Ester, (3S-(3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha))-, Thapsigargin [Chemical/Ingredient] 
A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.
National Institutes of Health

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11 relations

Broader (3)

Enzyme InhibitorsTerpenesTumor Promoters
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

L12ADT

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.
The UPR (unfolded protein response) or ER (endoplasmic reticulum) stress response was first described 20 years ago. The field of… 
Highly Cited
2007
Highly Cited
2007
Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes.
Highly Cited
2005
Highly Cited
2005
Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients.
Review
2001
Review
2001
Phosphorylation processes mediate rapid changes of brain aromatase activity
Highly Cited
2000
Highly Cited
2000
Thapsigargin induces a calmodulin/calcineurin‐dependent apoptotic cascade responsible for the death of prostatic cancer cells
New agents are required for the treatment of androgen‐independent prostate cancer. Due to the low rate of proliferation of these… 
Highly Cited
1996
Highly Cited
1996
Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis
Highly Cited
1995
Highly Cited
1995
Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability…
Highly Cited
1994
Highly Cited
1994
The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.
Calcium (Ca2+) accumulates within the endoplasmic reticulum of cells through function of the sarcoplasmic reticulum and… 
Highly Cited
1993
Highly Cited
1993
Roles of phospholipase C and Ca(2+)-ATPase in calcium responses of single, fibrinogen-bound platelets.
Highly Cited
1991
Highly Cited
1991
Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release.
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