Thapsigargin

Known as: Octanoic Acid, 6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2-methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)azuleno(4,5-b)furan-7-yl Ester, (3S-(3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha))-, Thapsigargin [Chemical/Ingredient] 
A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.

Topic mentions per year

Topic mentions per year

1979-2017
020040019792017

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Highly Cited
2011
Highly Cited
2011
Autophagy, a catabolic pathway that delivers cellular components to lysosomes for degradation, can be activated by stressful… (More)
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Highly Cited
2005
Highly Cited
2005
Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined… (More)
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Highly Cited
2003
Highly Cited
2003
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing… (More)
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Highly Cited
2001
Highly Cited
2001
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction… (More)
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Highly Cited
1995
Highly Cited
1995
Local increases in intracellular calcium ion concentration ([Ca2+]i) resulting from activation of the ryanodine-sensitive calcium… (More)
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Highly Cited
1991
Highly Cited
1991
The role of ATP-dependent calcium uptake into intracellular storage compartments is an essential feature of hormonally induced… (More)
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Highly Cited
1991
Highly Cited
1991
ATP-dependent calcium uptake by isolated sarcoplasmic reticulum vesicles is inhibited by concentrations of free thapsigargin as… (More)
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Highly Cited
1990
Highly Cited
1990
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many… (More)
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Highly Cited
1989
Highly Cited
1989
The depletion of an inositol 1, 4,5-trisphosphate-sensitive intracellular Ca2+ pool has been proposed to be the signal for Ca2… (More)
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Highly Cited
1989
Highly Cited
1989
Department of Clinical Chemistry, University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; 2 School of… (More)
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