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Thapsigargin

Known as: Octanoic Acid, 6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2-methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)azuleno(4,5-b)furan-7-yl Ester, (3S-(3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha))-, Thapsigargin [Chemical/Ingredient] 
A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.
National Institutes of Health

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11 relations

Broader (3)

Enzyme InhibitorsTerpenesTumor Promoters
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

L12ADT

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer.
BACKGROUND Standard anti-proliferative chemotherapy is relatively ineffective against slowly proliferating androgen-independent… 
Highly Cited
2003
Highly Cited
2003
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
Little is known about the expression and possible functions of unopposed gap junction hemichannels in the brain. Emerging… 
Highly Cited
2002
Highly Cited
2002
Structural changes in the calcium pump accompanying the dissociation of calcium
In skeletal muscle, calcium ions are transported (pumped) against a concentration gradient from the cytoplasm into the… 
Highly Cited
2000
Highly Cited
2000
ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1
ABSTRACT ATF6, a member of the leucine zipper protein family, can constitutively induce the promoter of glucose-regulated protein… 
Highly Cited
1997
Highly Cited
1997
Ca2+ Flow via Tunnels in Polarized Cells: Recharging of Apical Ca2+ Stores by Focal Ca2+ Entry through Basal Membrane Patch
Highly Cited
1994
Highly Cited
1994
Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein.
Highly Cited
1994
Highly Cited
1994
The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.
Calcium (Ca2+) accumulates within the endoplasmic reticulum of cells through function of the sarcoplasmic reticulum and… 
Highly Cited
1994
Highly Cited
1994
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
Highly Cited
1992
Highly Cited
1992
U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.
Highly Cited
1989
Highly Cited
1989
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the…
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