Skip to search formSkip to main contentSkip to account menu

Thalicarpine

Known as: 4H-dibenzo[de,g]quinoline, 9-[4, 5-dimethoxy-2-[(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, [S-(R*,R*)]- (9CI), [S-(R*,R*)]-9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)-methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline, 6a-Alpha-aporphine, 9-[[4,5-dimethoxy-alpha-((S)-1,2,3, 4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1, 2,10-trimethoxy- 
A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Aporphines
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Narrower (1)

Thaliblastine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Synthetic Oxoisoaporphine Alkaloids: In Vitro, In Vivo and In Silico Assessment of Antileishmanial Activities
Leishmaniasis is a growing health problem worldwide. As there are certain drawbacks with the drugs currently used to treat human… 
2013
2013
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives.
Highly Cited
1997
Highly Cited
1997
Inhibition of Eukaryote Protein Kinases by Isoquinoline and Oxazine Alkaloids
O 
1992
1992
Antitumor activity of thaliblastine (NSC-68075) in experimental ovarian tumor cell lines sensitive and resistant to cisplatin.
1980
1980
On the ability of N‐chloroethyl aporphine derivatives to cause irreversible inhibition of dopamine receptor mechanisms
The potential dopamine inhibitory properties of (‐)N‐(2‐chloroethyl)‐norapomorphine [(‐)NCA], (‐)N‐(hydroxyethyl)norapomorphine… 
1979
1979
Dimeric Aporphine-Benzylisoquinoline and Aporphine-Pavine Alkaloids.
1973
1973
Inhibition of macromolecular biosynthesis in cultured L1210 mouse leukemia cells by thalicarpine (NSC 68075).
The plant alkaloid thalicarpine inhibits the synthesis of DNA, RNA, and protein in cultured L1210 cells. Significant inhibition… 
1971
1971
Tumor inhibitors. II. Cytotoxic alkaloids from Annona purpurea.
Investigation of the cytotoxic principles of Annona purpurea L. resulted in the isolation and characterization of four new… 
1968
1968
Ocotea alkaloids: the chaacterization and structures of four new aporphine bases.
1967
1967
The constitution of thalicarpine.
Reinvestigation on the constitution of thalicarpine, previously, isolated from Thalictrum and Hernandia species, was descrived… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)