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AN ULTRASENSITIVE CAPTURE ELISA FOR DETECTION OF FASCIOLA HEPATICA COPROANTIGENS IN SHEEP AND CATTLE USING A NEW MONOCLONAL ANTIBODY (MM3)
TLDR
Results indicate that this assay is a reliable and ultrasensitive method for detecting subnanogram amounts of F. hepatica antigens in feces from sheep and cattle, facilitating early diagnosis. Expand
Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin.
TLDR
Results indicate that MA modulates the expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorogenesis, inflammation and various autoimmune diseases, and raise the possibility that it may be of value in the treatment of inflammatory diseases and/or cancer. Expand
Proteomics, networks and connectivity indices
TLDR
This work reviews and comment on the challenges and new trends in the definition and applications of CIs in Proteomics, and focuses on CIs to describe Protein Interaction Networks or RNA co‐expression networks. Expand
Association between anti-F. hepatica antibody levels in milk and production losses in dairy cows.
TLDR
It is concluded that MM3-SERO ELISA is a powerful tool that can be successfully applied, if appropriate "economic thresholds" are established, to identify herds and cows suffering from milk production losses associated with natural infection by F. hepatica. Expand
Anisakis simplex: the high prevalence in Madrid (Spain) and its relation with fish consumption.
TLDR
Positivity was more prevalent among subjects who habitually consumed fresh and possibly undercooked fish than among those who generally consumed frozen fish or boiled or baked fish, and no evidence of cross-reactivity between the ELISA and other allergens was found. Expand
Prevalence of and risk factors for IgE sensitization to Anisakis simplex in a Spanish population
TLDR
The objective was to investigate the prevalence of and risk factors for IgE sensitization to A. simplex in Galicia, a region of northwestern Spain with a population of about 3 million and high average fish consumption (78.5 g/person per day). Expand
Predicting antimicrobial drugs and targets with the MARCH-INSIDE approach.
TLDR
The use of MARCH-INSIDE to generate macromolecular TIs and TPGIs for proteins or RNA targets for antimicrobial drugs and multi-target sto-TIs which unifying QSAR models predicting antifungal, antibacterial, or anti-parasite drugs with multiple targets (microbial species). Expand
MM3-ELISA evaluation of coproantigen release and serum antibody production in sheep experimentally infected with Fasciola hepatica and F. gigantica.
TLDR
During an experimental infection of sheep with Fasciola hepatica or F. gigantica, MM3-SERO andMM3-COPRO ELISA tests were applied to compare the kinetics of antibody production and coproantigen release between the 2nd and 32nd week post-infection, demonstrating the usefulness of these tests for the diagnosis of early as well as long-term fascioliasis infections. Expand
Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin.
TLDR
Results suggest that components of Vimang, including the polyphenol mangiferin, have depressor effects on the phagocytic and ROS production activities of rat macrophages and, thus, that they may be of value in the treatment of diseases of immunopathological origin characterized by the hyperactivation of phagocyte cells such as certain autoimmune disorders. Expand
A recombinant enolase from Anisakis simplex is differentially recognized in natural human and mouse experimental infections
TLDR
The results seem to indicate that, during natural infection in humans, A. simplex larvae do not offer sufficient antigenic stimulus to induce anti-enolase antibodies. Expand
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