Tacrolimus Binding Proteins

ABSTRACT Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating… Expand

BackgroundThere is a rapidly increasing amount of de novo genome assembly using next-generation sequencing (NGS) short reads… Expand

Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms… Expand

The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin… Expand

Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B… Expand

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage… Expand

THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting… Expand

Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… Expand

Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their… Expand

FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal… Expand