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Tacrolimus Binding Proteins

Known as: Protein, FK-506-Binding, FK 506 Binding Protein, FK-506-Binding Protein 
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (14)

BDBT protein, DrosophilaFKBP-13FKBP1A protein, humanFKBP1b protein, rat

Broader (3)

Carrier ProteinsDNA-Binding ProteinsHeat shock proteins
FKBP5 protein, humanIn BloodIsomeraseLigand Binding

Papers overview

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Highly Cited
2012
Highly Cited
2012
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler
BackgroundThere is a rapidly increasing amount of de novo genome assembly using next-generation sequencing (NGS) short reads… 
Highly Cited
2011
Highly Cited
2011
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms… 
Highly Cited
2002
Highly Cited
2002
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Highly Cited
2000
Highly Cited
2000
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor…
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B… 
Highly Cited
1995
Highly Cited
1995
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage… 
Highly Cited
1994
Highly Cited
1994
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting… 
Highly Cited
1992
Highly Cited
1992
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… 
Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Highly Cited
1991
Highly Cited
1991
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal… 
Review
1985
Review
1985
Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells
Epstein–Barr virus (EBV) infects human B lymphocytes, transforming the infected cells into dividing blasts that can proliferate… 
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