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Tacrolimus Binding Proteins
Known as:
Protein, FK-506-Binding
, FK 506 Binding Protein
, FK-506-Binding Protein
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A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
National Institutes of Health
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Related topics
Related topics
28 relations
Narrower (14)
BDBT protein, Drosophila
FKBP-13
FKBP1A protein, human
FKBP1b protein, rat
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Broader (3)
Carrier Proteins
DNA-Binding Proteins
Heat shock proteins
FKBP5 protein, human
In Blood
Isomerase
Ligand Binding
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Emerging views of mitophagy in immunity and autoimmune diseases
Y. Xu
,
J. Shen
,
Z. Ran
Autophagy
2019
Corpus ID: 96449285
ABSTRACT Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating…
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Highly Cited
2012
Highly Cited
2012
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler
Ruibang Luo
,
Binghang Liu
,
+27 authors
J. Wang
GigaScience
2012
Corpus ID: 2681931
BackgroundThere is a rapidly increasing amount of de novo genome assembly using next-generation sequencing (NGS) short reads…
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Highly Cited
2011
Highly Cited
2011
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
D. Baker
,
Tobias Wijshake
,
+5 authors
J. Deursen
Nature
2011
Corpus ID: 4340190
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms…
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Highly Cited
2002
Highly Cited
2002
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
R. Loewith
,
E. Jacinto
,
+6 authors
M. Hall
Molecular cell
2002
Corpus ID: 8189750
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin…
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Highly Cited
2000
Highly Cited
2000
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor…
H. Zhong
,
K. Chiles
,
+5 authors
G. Semenza
Cancer research
2000
Corpus ID: 25671330
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B…
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Highly Cited
1995
Highly Cited
1995
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
T. McDaniel
,
K. Jarvis
,
M. Donnenberg
,
J. Kaper
Proceedings of the National Academy of Sciences…
1995
Corpus ID: 33182237
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage…
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Highly Cited
1994
Highly Cited
1994
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
E. Brown
,
M. W. Albers
,
+4 authors
S. Schreiber
Nature
1994
Corpus ID: 4359651
THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting…
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Highly Cited
1992
Highly Cited
1992
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
C. Counter
,
A. A. Avilion
,
+4 authors
S. Bacchetti
The EMBO journal
1992
Corpus ID: 14763231
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication…
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Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
J. Liu
,
Jesse D. Farmer
,
Willam S. Lane
,
J. Friedman
,
S. Schreiber
Cell
1991
Corpus ID: 22094672
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their…
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Highly Cited
1991
Highly Cited
1991
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
J. Heitman
,
N. Movva
,
M. Hall
Science
1991
Corpus ID: 9937225
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal…
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