Tacrolimus Binding Proteins

Known as: Protein, FK-506-Binding, FK 506 Binding Protein, FK-506-Binding Protein 
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
National Institutes of Health

Related topics

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26 relations

Narrower (12)

BDBT protein, DrosophilaFKBP-13FKBP1A protein, humanFKBP1b protein, rat
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Broader (3)

Carrier ProteinsDNA-Binding ProteinsHeat shock proteins
FKBP5 protein, humanIn BloodIsomeraseLigand Binding
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Papers overview

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Highly Cited
2010
Highly Cited
2010
INTCAL 09 AND MARINE 09 RADIOCARBON AGE CALIBRATION CURVES , 0 – 50 , 000 YEARS
The IntCal04 and Marine04 radiocarbon calibration curves have been updated from 12 cal kBP (cal kBP is here defined as thousands… (More)
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Highly Cited
2005
Highly Cited
2005
Distribution and intensity of constraint in mammalian genomic sequence.
Comparisons of orthologous genomic DNA sequences can be used to characterize regions that have been subject to purifying… (More)
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Highly Cited
2002
Highly Cited
2002
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin… (More)
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Highly Cited
2000
Highly Cited
2000
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor…
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B… (More)
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Highly Cited
1998
Highly Cited
1998
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis.
Expression of the pro-apoptotic molecule BAX has been shown to induce cell death. While BAX forms both homo- and heterodimers… (More)
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Highly Cited
1995
Highly Cited
1995
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage… (More)
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Highly Cited
1994
Highly Cited
1994
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting… (More)
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Highly Cited
1993
Highly Cited
1993
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.
To date, apoptosis has been characterized biochemically by the production of 180-200 bp internucleosomal DNA fragments resulting… (More)
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Highly Cited
1992
Highly Cited
1992
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… (More)
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Highly Cited
1991
Highly Cited
1991
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal… (More)
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