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Tacrolimus Binding Proteins

Known as: Protein, FK-506-Binding, FK 506 Binding Protein, FK-506-Binding Protein 
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
National Institutes of Health

Papers overview

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Review
2019
Review
2019
ABSTRACT Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating… Expand
Highly Cited
2012
Highly Cited
2012
BackgroundThere is a rapidly increasing amount of de novo genome assembly using next-generation sequencing (NGS) short reads… Expand
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Highly Cited
2011
Highly Cited
2011
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms… Expand
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Highly Cited
2002
Highly Cited
2002
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin… Expand
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Highly Cited
2000
Highly Cited
2000
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B… Expand
Highly Cited
1995
Highly Cited
1995
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage… Expand
Highly Cited
1994
Highly Cited
1994
THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting… Expand
Highly Cited
1992
Highly Cited
1992
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… Expand
Highly Cited
1991
Highly Cited
1991
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their… Expand
Highly Cited
1991
Highly Cited
1991
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal… Expand