Tacrolimus Binding Proteins

Known as: Protein, FK-506-Binding, FK 506 Binding Protein, FK-506-Binding Protein 
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The IntCal04 and Marine04 radiocarbon calibration curves have been updated from 12 cal kBP (cal kBP is here defined as thousands… (More)
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Highly Cited
2005
Highly Cited
2005
Comparisons of orthologous genomic DNA sequences can be used to characterize regions that have been subject to purifying… (More)
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Highly Cited
2002
Highly Cited
2002
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin… (More)
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Highly Cited
2000
Highly Cited
2000
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B… (More)
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Highly Cited
1998
Highly Cited
1998
Expression of the pro-apoptotic molecule BAX has been shown to induce cell death. While BAX forms both homo- and heterodimers… (More)
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Highly Cited
1995
Highly Cited
1995
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage… (More)
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Highly Cited
1994
Highly Cited
1994
THE structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting… (More)
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Highly Cited
1993
Highly Cited
1993
To date, apoptosis has been characterized biochemically by the production of 180-200 bp internucleosomal DNA fragments resulting… (More)
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Highly Cited
1992
Highly Cited
1992
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… (More)
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Highly Cited
1991
Highly Cited
1991
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal… (More)
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