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RNA-guided genetic silencing systems in bacteria and archaea
Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNAExpand
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Structural basis for CRISPR RNA-guided DNA recognition by Cascade
The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids. In Escherichia coli, immunityExpand
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Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
CRISPR Processing Many bacteria and archaea recognize invading viruses and plasmids. Foreign DNA is integrated into so-called clustered regularly interspaced short palindromic repeat (CRISPR) loci,Expand
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RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
Prokaryotes have evolved multiple versions of an RNA-guided adaptive immune system that targets foreign nucleic acids. In each case, transcripts derived from clustered regularly interspaced shortExpand
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Structures of the RNA-guided surveillance complex from a bacterial immune system
Bacteria and archaea acquire resistance to viruses and plasmids by integrating short fragments of foreign DNA into clustered regularly interspaced short palindromic repeats (CRISPRs). TheseExpand
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Comparative Genomic Analysis of Hyperthermophilic Archaeal Fuselloviridae Viruses
ABSTRACT The complete genome sequences of two Sulfolobus spindle-shaped viruses (SSVs) from acidic hot springs in Kamchatka (Russia) and Yellowstone National Park (United States) have beenExpand
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Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems, whichExpand
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Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli
A foreign-DNA–destroying machine Bacteria have an adaptive immune system, called CRISPR, that identifies invading viruses through their DNA or RNA sequences and cuts them up (see the Perspective byExpand
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CRISPR-mediated adaptive immune systems in bacteria and archaea.
Effective clearance of an infection requires that the immune system rapidly detects and neutralizes invading parasites while strictly avoiding self-antigens that would result in autoimmunity. TheExpand
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Mechanism of foreign DNA selection in a bacterial adaptive immune system.
In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading bacteriophage or plasmids are integrated into CRISPR loci within the host genome, conferring immunity against subsequentExpand
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