FAQ

FKBP5 protein, human

Known as: Peptidyl-Prolyl Cis-Trans Isomerase FKBP5, FKBP5, EC 5.2.1.8 
Peptidyl-prolyl cis-trans isomerase FKBP5 (457 aa, ~51 kDa) is encoded by the human FKBP5 gene. This protein plays a role in the mediation of protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
0102019932017

Related topics

Related topics

11 relations
Cell NucleusCytoplasmic matrixEnzyme GeneFKBP5 gene
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Broader (1)

FK506 binding protein 5

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
FKBP5 protein, human
Cell Nucleus
Signal Transduction
Cytoplasmic matrix
protein protein interaction
Tacrolimus Binding Proteins

Papers overview

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2014
2014
FKBP5 Genotype-Dependent DNA Methylation and mRNA Regulation After Psychosocial Stress in Remitted Depression and Healthy Controls
BACKGROUND Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor… (More)
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Highly Cited
2013
Highly Cited
2013
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape development and function of the human… (More)
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2013
2013
Glucocorticoid Receptor and FKBP5 Expression Is Altered Following Exposure to Chronic Stress: Modulation by Antidepressant Treatment
Major depression is thought to originate from the interaction between susceptibility genes and adverse environmental events, in… (More)
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2012
2012
The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.
Chronic stress is increasingly considered to be a main risk factor for the development of a variety of psychiatric diseases such… (More)
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2012
2012
Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
Childhood trauma is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Both factors increase risk for… (More)
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Highly Cited
2010
Highly Cited
2010
Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
Childhood trauma is associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation and is a known risk factor for… (More)
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2010
2010
DNA sequence variants of the FKBP5 gene are associated with unipolar depression.
FKBP5 is a glucocorticoid receptor-regulating co-chaperone of hsp-90 and, therefore, is suggested to play a role in the… (More)
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2006
2006
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.
Androgen signaling via the androgen receptor (AR) transcription factor is crucial to normal prostate homeostasis and prostate… (More)
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Highly Cited
2005
Highly Cited
2005
Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children
SIR—Recently, Binder et al reported association between two polymorphisms (rs3800373, rs1360780) in the FKBP5 gene, a… (More)
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Highly Cited
2004
Highly Cited
2004
Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids.
Expression of FKBP51, a large molecular weight immunophilin, is strongly enhanced by glucocorticoids, progestins, and androgens… (More)
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