I. Hutchinson

Publications318
h-index56
Citations13,242
Highly Influential Citations518
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An investigation of polymorphism in the interleukin-10 gene promoter.
Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We… Expand
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Association between functional polymorphism in EGF gene and malignant melanoma
BACKGROUND Malignant melanoma, the most serious cutaneous malignancy, has attracted substantial attention because of its rapidly increasing incidence and the poor prognosis of some tumours. Little is… Expand
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Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation.
BACKGROUND Transforming growth factor (TGF)-beta1 is a profibrogenetic cytokine that has been implicated in the development of fibrosis in transplanted tissues. In this study, we have analyzed the… Expand
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A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production.
We have described previously a variable length CA repeat sequence in the first intron of the human IFN-gamma gene and showed that allele #2 is associated with high in vitro IFN-gamma production. In a… Expand
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Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection.
Acute rejection is a major cause of reduced survival of renal allografts. Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells and is expressed widely by renal tissue and T… Expand
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In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.
The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region… Expand
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Cytokine gene polymorphisms predict acute graft rejection following renal transplantation.
BACKGROUND The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of acute rejection, while animal models suggest a role for interleukin-10… Expand
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Cytokine gene polymorphism and heart transplant rejection.
BACKGROUND Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have… Expand
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Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?
Background and aims: Inflammation may play a role in the pathogenesis of irritable bowel syndrome in some individuals, such as in those who develop symptoms following a dysenteric illness. Persisting… Expand
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Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus.
OBJECTIVE To investigate interleukin 10 (IL-10) gene promoter polymorphisms in systemic lupus erythematosus (SLE) and its clinical subsets. METHODS DNA from 76 Caucasian patients with SLE and 119… Expand
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