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TYK2 Kinase

Known as: TYK2 Kinase [Chemical/Ingredient], Non Receptor Tyrosine Protein Kinase TYK2, Non-Receptor Tyrosine-Protein Kinase TYK2 
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
  • E. Choy
  • Rheumatology
  • 2019
  • Corpus ID: 54625758
Abstract Cytokines are key drivers of inflammation in RA, and anti-cytokine therapy has improved the outcome of RA. Janus Kinases… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile… Expand
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Highly Cited
2010
Highly Cited
2010
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals… Expand
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Highly Cited
2010
Highly Cited
2010
To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622… Expand
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Review
2009
Review
2009
Summary:  The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non‐receptor protein tyrosine… Expand
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Highly Cited
2003
Highly Cited
2003
Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-β (IFN-β) in a MyD88-independent… Expand
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Highly Cited
2002
Highly Cited
2002
IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a novel cytokine-like subunit related… Expand
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Highly Cited
2001
Highly Cited
2001
The reversible tyrosine phosphorylation of proteins, modulated by the coordinated actions of protein-tyrosine kinases and protein… Expand
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Highly Cited
2000
Highly Cited
2000
To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/- mice. In contrast to other Jaks, where… Expand
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Highly Cited
1992
Highly Cited
1992
Abstract The mutant human cell line 11,1 is unresponsive to interferon α. Here we describe the genetic complementation of this… Expand
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