TYK2 Kinase

Known as: TYK2 Kinase [Chemical/Ingredient], Non Receptor Tyrosine Protein Kinase TYK2, Non-Receptor Tyrosine-Protein Kinase TYK2 
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of… (More)
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile… (More)
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Highly Cited
2011
Highly Cited
2011
Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse… (More)
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Highly Cited
2010
Highly Cited
2010
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals… (More)
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Review
2009
Review
2009
The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They… (More)
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Highly Cited
2003
Highly Cited
2003
The four mammalian Jak tyrosine kinases are non-covalently associated with cell surface receptors binding helical bundled… (More)
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Highly Cited
2003
Highly Cited
2003
Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-β (IFN-β) in a MyD88-independent… (More)
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Highly Cited
2000
Highly Cited
2000
To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/- mice. In contrast to other Jaks, where… (More)
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Highly Cited
1995
Highly Cited
1995
Interleukin (IL-12) has many effects on the function of natural killer and T cells, and is important in the control of cell… (More)
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Highly Cited
1995
Highly Cited
1995
IL-10 affects monocytes and T cells by driving the progression of immune responsiveness such that Th2 lymphocyte-mediated effects… (More)
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Highly Cited
1992
Highly Cited
1992
The mutant human cell line 11.1 is unresponsive to interferon alpha. Here we describe the genetic complementation of this mutant… (More)
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