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TYK2 gene

Known as: TYROSINE KINASE 2, JTK1, TYK2 
This gene is involved in both protein phosphorylation and interferon-mediated signaling.
National Institutes of Health

Papers overview

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2017
2017
Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a high‐grade NSCLC characterized by poor prognosis and resistance to… Expand
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Highly Cited
2016
Highly Cited
2016
BACKGROUND Recurrence and/or metastasis occurs in more than half of patients with head and neck squamous cell carcinoma (HNSCC… Expand
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Highly Cited
2016
Highly Cited
2016
Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically… Expand
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2015
2015
Pancreatic β-cells are destroyed by an autoimmune attack in type 1 diabetes. Linkage and genome-wide association studies point to… Expand
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Highly Cited
2009
Highly Cited
2009
In a recent genome-wide association study (GWAS) based on 12 374 non-synonymous single nucleotide polymorphisms we identified a… Expand
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Highly Cited
2009
Highly Cited
2009
Glycogen synthase kinase-3β (GSK-3β)-modulated IFN-γ-induced inflammation has been reported; however, the mechanism that… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVES This is a family-based association study to investigate the genetic contribution of tyrosine kinase 2 (TYK2 ) to… Expand
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Highly Cited
2005
Highly Cited
2005
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by both genetic and environmental factors… Expand
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Highly Cited
1996
Highly Cited
1996
Thanatophoric dwarfism (TD) is a sporadic lethal skeletal dysplasia with micromelic shortening of the limbs, macrocephaly… Expand
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Highly Cited
1990
Highly Cited
1990
Tyrosine phosphorylation is important in the transmission of growth and differentiation signals; known tyrosine kinases include… Expand
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