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TYK2 gene

Known as: TYROSINE KINASE 2, JTK1, TYK2 
This gene is involved in both protein phosphorylation and interferon-mediated signaling.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Differentiation processCell ProliferationHomo sapiensInterferon Signaling Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Protein tyrosine kinase 2: a novel therapeutic target to overcome acquired EGFR-TKI resistance in non-small cell lung cancer
BackgroundProtein tyrosine kinase 2 (PTK2) expression has been reported in various types of human epithelial cancers including… 
2018
2018
First‐in‐Human Phase I Study of AC0010, a Mutant‐Selective EGFR Inhibitor in Non–Small Cell Lung Cancer: Safety, Efficacy, and Potential Mechanism of Resistance
Review
2017
Review
2017
ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non–Small Cell Lung Cancer
Highly Cited
2016
Highly Cited
2016
Comprehensive Characterization of Oncogenic Drivers in Asian Lung Adenocarcinoma
Highly Cited
2013
Highly Cited
2013
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively‐activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
Review
2011
Review
2011
The hyperimmunoglobulin E syndrome - clinical manifestation diversity in primary immune deficiency
The hyper-IgE syndromes are rare, complex primary immunodeficiencies characterized by clinical manifestation diversity, by… 
2008
2008
Human T-cell leukemia virus type 1 blunts signaling by interferon alpha.
Highly Cited
2007
Highly Cited
2007
Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families.
OBJECTIVES This is a family-based association study to investigate the genetic contribution of tyrosine kinase 2 (TYK2 ) to… 
Highly Cited
1996
Highly Cited
1996
Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1).
Thanatophoric dwarfism (TD) is a sporadic lethal skeletal dysplasia with micromelic shortening of the limbs, macrocephaly… 
Highly Cited
1990
Highly Cited
1990
Putative tyrosine kinases expressed in K-562 human leukemia cells.
Tyrosine phosphorylation is important in the transmission of growth and differentiation signals; known tyrosine kinases include… 
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