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TYK2 gene

Known as: TYROSINE KINASE 2, JTK1, TYK2 
This gene is involved in both protein phosphorylation and interferon-mediated signaling.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Differentiation processCell ProliferationHomo sapiensInterferon Signaling Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
P349 Cyclosporine has no clinically meaningful effect on pharmacokinetics (PK) of BMS-986165, an oral selective tyrosine kinase 2 (TYK2) inhibitor, in healthy subjects
2010
2010
Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease.
Atherosclerosis is initiated by adhesion and infiltration of inflammatory leukocytes into the intima, where non-receptor protein… 
2008
2008
Genetic origins of hyper-IgE syndrome
Hyper-IgE syndrome (HIES) is a complex primary immunodeficiency characterized by high serum IgE, chronic eczematoid dermatitis… 
2007
2007
The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor
Recurrent missense fibroblast growth factor receptor 3 (FGFR3) mutations have been ascribed to skeletal dysplasias of variable… 
2005
2005
Critical Role of Proline-Rich Tyrosine Kinase 2 in Reversion of the Adhesion-Mediated Suppression of Reactive Oxygen Species Generation by Human Neutrophils1
Neutrophils act as the first line of innate immune defense against invading microorganisms during infection and inflammation. The… 
2005
2005
Design of Selective Inhibitors of Tyrosine Kinase 2
Selective inhibitors of tyrosine kinase 2 (Tyk2) were searched for using database screening, de novo ligand design and… 
2003
2003
Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus
2001
2001
Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2.
Hic-5 and paxillin, members of the LIM protein family, have been shown to be localized in focal adhesion and to have a role in… 
2001
2001
Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src
The anti-inflammatory effects of salicylate are well known, but the intracellular mechanisms underlying those effects remain to… 
Highly Cited
1990
Highly Cited
1990
Putative tyrosine kinases expressed in K-562 human leukemia cells.
Tyrosine phosphorylation is important in the transmission of growth and differentiation signals; known tyrosine kinases include… 
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