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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
TLDR
The results show that LKB1 functions as a master upstream protein kinase, regulating AMPK‐related kinases as well as AMPK, and may mediate the physiological effects of L KB1, including its tumour suppressor function. Expand
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
TLDR
These results provide the first description of a physiological substrate for the LKB1 tumor suppressor and suggest that it functions as an upstream regulator of AMPK. Expand
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor
TLDR
It is found that isolated human primary lymphatic and blood vascular endothelial cells show interesting differences in gene expression relevant for their distinct functions in vivo, and overexpression of the homeobox transcription factor Prox‐1 in the BECs is suggested to act as a cell proliferation inducer and a fate determination factor for the LECs. Expand
Association of Cdk-activating kinase subunits with transcription factor TFIIH
TLDR
Two polypeptides of the purified mammalian TFIIH are the MO15/Cdk7 kinase and cyclin H subunits of the Cdk-activating kinase Cak, previously identified as a positive regulator of Cdc2 and Cdk2. Expand
PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis
TLDR
Functional analysis of an AMPKα1 species carrying a non‐phosphorylatable mutation at Ser‐173 revealed a critical function of this phosphorylation for efficient release of free fatty acids and glycerol in response to PKA‐activating signals, suggesting a new mechanism of negative regulation of AMPK activity by PKA that is important for converting a lipolytic signal into an effectivelipolytic response. Expand
BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response*
TLDR
It is shown that human Top BP1 is required for DNA replication and that it interacts with DNA polymerase ε and that TopBP1 interacts with the checkpoint protein hRad9, suggesting a role in rescue of stalled forks. Expand
FGFR‐4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
TLDR
The results suggest that FGFR‐4 along with other fibroblast growth factor receptors performs cell lineage and tissue‐specific functions. Expand
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
TLDR
The selective growth advantage conferred by Rb gene deletion during tumorigenesis may be explained in part by changes in the regulation of cyclin E. Expand
p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint*
TLDR
The mechanism by which p21 can contribute to this arrest in G2 is addressed, and data show that a cell is equipped with at least two independent pathways to ensure efficient inhibition of Cdc2 activity in response to DNA damage. Expand
Integrated network analysis platform for protein-protein interactions
TLDR
This work introduces a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools and demonstrated the advantages of PINA by analyzing two human PPI networks. Expand
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