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Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum.
TLDR
The release of Sph-1-P from activated platelets may be involved in a variety of physiological and pathophysiological processes, including thrombosis, hemostasis, atherosclerosis and wound healing.
Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells.
TLDR
Sph-1-P, rather than LPA, is a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells, under the conditions in which critical platelet-endothelial interactions occur.
Metabolism and functional effects of sphingolipids in blood cells
TLDR
It is suggested that all blood cells may remove plasma Sph, which is harmful or suppressive to cellular functions, and change it into Sph‐1‐P, acting as the source of plasma Sph; which may play a variety of important roles in blood vessels.
Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling.
TLDR
Compared with the aggregation response of wild-type platelets, that of FcR gamma-chain-deficient platelets in response to vWF plus botrocetin was impaired, implying that Fc R gamma- chain is required for the full activation of platelets mediated by GPIb.
Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).
TLDR
It is suggested that Rac and/or PAK activation, but not Rho, may play certain roles in platelet spreading via integrin alpha(2)beta(1) and that Src family kinases and PI3-kinase participate in these processes.
Cobalt hematoporphyrin inhibits CLEC-2-podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice.
The platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) interacts with podoplanin on the surface of certain types of tumor cells, and this interaction facilitates tumor metastasis.
Sphingosine 1-phosphate-related metabolism in the blood vessel.
TLDR
Although Sph-1-P is stable in the plasma, it is likely that the level of this bioactive lipid is dynamically controlled by various factors including release from platelets, distribution among plasma proteins, and degradation by ectophosphatase.
Effect of Sarpogrelate, a 5-HT2A Antagonist, on Platelet Aggregation in Patients with Ischemic Stroke: Clinical-Pharmacological Dose-Response Study
TLDR
Sarpogrelate treatment inhibited platelet aggregation dose-dependently in patients with ischemic stroke, as judged by a new assessment system employing combinations of 5-HT and epinephrine as agonists.
Detection of platelet aggregates with a particle counting method using light scattering.
TLDR
The new device appeared to be particularly sensitive to small aggregates such as those formed in platelet activation induced by low concentrations of agonists, and allows the aggregate size distribution and the extent of aggregation to be estimated.
C‐type lectin‐like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor‐bearing mice
TLDR
CLEC‐2 depletion prolongs cancer survival by suppressing thrombosis and inflammation and inhibits hematogenous tumor metastasis of podoplanin‐expressing B16F10 cells.
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