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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
The results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development.
Molecular regulation of angiogenesis and lymphangiogenesis
The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell–cell communication.
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
- H. Augustin, G. Koh, G. Thurston, K. Alitalo
- BiologyNature Reviews Molecular Cell Biology
- 1 March 2009
The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system and provide unique insights into the functions of this vascular signalling system.
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).
- M. Achen, M. Jeltsch, S. Stacker
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 20 January 1998
A member of the VEGF family is identified by computer-based homology searching and it is demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other V EGF family members and that corresponds to the mature form of VEGf-C.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- Aleksanteri Aspelund, Salli Antila, K. Alitalo
- Biology, ChemistryThe Journal of experimental medicine
- 29 June 2015
The presence of a lymphatic vessel network in the dura mater of the mouse brain is discovered and it is shown that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
VEGF-C is a novel regulator of endothelia, and its effects may extend beyond the lymphatic system, where Flt4 is expressed.
A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.
VEGF‐C is a novel regulator of endothelia, and its effects may extend beyond the lymphatic system, where Flt4 is expressed.
Proteolytic processing regulates receptor specificity and activity of VEGF‐C
The role of post‐translational processing in VEGF‐C secretion and function is analysed, and novel structure–function relationships in the PDGF/VEGF family are revealed.
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
- A. Kaipainen, J. Korhonen, K. Alitalo
- BiologyProceedings of the National Academy of Sciences…
- 11 April 1995
The results suggest that FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues, and support the theory on the venous origin of lymphatic Vessels.