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Janus kinase

Known as: JAK Kinases, JAK kinase, Janus Kinases 
A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS… 
National Institutes of Health

Related topics

Related topics

14 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Narrower (5)

Janus kinase 1Janus kinase 2TK5TYK2 Kinase

Broader (1)

Protein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Targeting cytokine signaling in autoimmunity: back to the future and beyond.
Review
2015
Review
2015
Microbial amphiphiles: a class of promising new-generation anticancer agents.
Highly Cited
2011
Highly Cited
2011
The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats.
Highly Cited
2009
Highly Cited
2009
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
Protein tyrosine kinases of the Janus kinase (JAK) family are associated with many cytokine receptors, which, on ligand binding… 
Highly Cited
2004
Highly Cited
2004
Increased Myeloproliferation in Glutathione S-Transferase π-deficient Mice Is Associated with a Deregulation of JNK and Janus Kinase/STAT Pathways*
It has been shown that glutathione S-transferase π (GSTπ) interacts with and suppresses the activity of c-Jun NH2-terminal kinase… 
Review
2002
Review
2002
Molecular basis of the cell specificity of cytokine action.
1998
1998
Expression of a tyrosine phosphorylated, DNA binding Stat3β dimer in bacteria
Review
1996
Review
1996
Janus kinases in cytokine signalling.
Hematopoiesis is largely regulated by the binding of cytokines to receptors of the cytokine receptor superfamily. Although… 
Highly Cited
1995
Highly Cited
1995
Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone (*)
The mechanisms by which the binding of growth hormone (GH) to its cell surface receptor elicits changes in gene transcription are… 
1995
1995
The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3
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