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Janus kinase

Known as: JAK Kinases, JAK kinase, Janus Kinases 
A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting cytokines and cytokine receptors with… Expand
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Review
2018
Review
2018
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Preclinical studies suggest that Reed-Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune… Expand
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Review
2013
Review
2013
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Treatment options for myelofibrosis are limited. We evaluated the efficacy and safety of ruxolitinib, a potent and… Expand
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Highly Cited
2003
Highly Cited
2003
Constitutively activated, tyrosine-phosphorylated signal transducer and activator of transcription (STAT) 3 plays a pivotal role… Expand
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Highly Cited
2001
Highly Cited
2001
We have identified a new mammalian protein arginine N-methyltransferase, PRMT5, formerly designated Janus kinase-binding protein… Expand
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Highly Cited
1995
Highly Cited
1995
In mammals, many cytokines and growth factors stimulate members of the Janus kinase (JAK) family to transduce signals for the… Expand
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Review
1995
Review
1995
  • J. Ihle
  • Nature
  • 1995
  • Corpus ID: 4320606
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon… Expand
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Highly Cited
1994
Highly Cited
1994
MANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic… Expand
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