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Janus kinase 1

Known as: JAK1 Protein Tyrosine Kinase, JAK-1 Protein Tyrosine Kinase, JAK1 
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.
National Institutes of Health

Related topics

Related topics

14 relations
In BloodJAK1 geneJAK3 geneProcess of secretion

Narrower (2)

JAK1 protein, humanjak1 protein, zebrafish

Broader (1)

Janus kinase

Papers overview

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Highly Cited
2015
Highly Cited
2015
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
Highly Cited
2012
Highly Cited
2012
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
We investigated the therapeutic potential of JQ1, an inhibitor of the BET class of human bromodomain proteins, in B-cell acute… 
Highly Cited
2002
Highly Cited
2002
Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line
IL (interleukin)-22 is an IL-10-related cytokine; its main biological activity known thus far is the induction of acute phase… 
Highly Cited
2001
Highly Cited
2001
TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B*
The reversible tyrosine phosphorylation of proteins, modulated by the coordinated actions of protein-tyrosine kinases and protein… 
Highly Cited
1995
Highly Cited
1995
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.
The cytokines interleukin 2 (IL-2) and IL-15 have similar biological effects on T cells and bind common hematopoietin receptor… 
Highly Cited
1995
Highly Cited
1995
Jak-STAT signaling induced by the v-abl oncogene.
The effect of the v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) on the Jak-STAT pathway of cytokine signal… 
Highly Cited
1994
Highly Cited
1994
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains… 
Highly Cited
1994
Highly Cited
1994
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
The interleukin 6 receptor-associated signal transducer, gp130, is shared by receptor complexes for leukemia inhibitory factor… 
Highly Cited
1994
Highly Cited
1994
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes
The class II transactivator (CIITA) has been shown to be required for major histocompatibility complex (MHC) class II gene… 
Highly Cited
1991
Highly Cited
1991
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
The protein-tyrosine kinases (PTKs) are a burgeoning family of proteins, each of which bears a conserved domain of 250 to 300… 
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