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Janus kinase 1

Known as: JAK1 Protein Tyrosine Kinase, JAK-1 Protein Tyrosine Kinase, JAK1 
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.
National Institutes of Health

Related topics

Related topics

14 relations
In BloodJAK1 geneJAK3 geneProcess of secretion

Narrower (2)

JAK1 protein, humanjak1 protein, zebrafish

Broader (1)

Janus kinase

Papers overview

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2019
2019
The IκB Kinase Inhibitor ACHP Targets the STAT3 Signaling Pathway in Human Non-Small Cell Lung Carcinoma Cells
STAT3 is an oncogenic transcription factor that regulates the expression of genes which are involved in malignant transformation… 
2013
2013
The Janus Kinases Inhibitor AZD1480 Attenuates Growth of Small Cell Lung Cancers In Vitro and In Vivo
Purpose: The prognosis of small cell lung cancer (SCLC) is poor, and there has been very little progress in the medical treatment… 
Review
2012
Review
2012
Selective JAK1 inhibitor and selective Tyk2 inhibitor patents
Introduction: The JAK family comprises of the four non-receptor tyrosine kinases JAK1, JAK2, JAK3 and Tyk2, which play key, but… 
2007
2007
JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism.
von Hippel-Lindau (VHL) disease is a cancer syndrome, which includes renal cell carcinoma (RCC), and is caused by VHL mutations… 
2004
2004
Two members of the JAK family of protein tyrosine kinases map to Chromosomes 1p31.3 and 9p24
A member of a new class of protein tyrosine kinases, JAK1, has been mapped to 1p31.3 by in situ hybridization and Southern blot… 
2003
2003
YXXL Motifs in SH2-Bβ Are Phosphorylated by JAK2, JAK1, and Platelet-derived Growth Factor Receptor and Are Required for Membrane Ruffling*
SH2-Bβ binds to the activated form of JAK2 and various receptor tyrosine kinases. It is a potent stimulator of JAK2, is required… 
2002
2002
Cytokine G-protein signaling crosstalk in cardiomyocytes: Attentuation of Jak-STAT activation by endothelin-1
The IL-6-related cytokines, LIF and cardiotrophin-1, are important growth promoting and cardioprotective agents for… 
1997
1997
Effect of recombinant interleukin-6 and thrombopoietin on isolated guinea pig bone marrow megakaryocyte protein phosphorylation and proplatelet formation.
Guinea pig bone marrow megakaryocytes were isolated and cultured on collagen gels to promote proplatelet formation. In control… 
1995
1995
Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts
A number of cytokines have been shown to exert their effects via a recently discovered signaling cascade. One step in this… 
Highly Cited
1994
Highly Cited
1994
Erythropoietin and interleukin-2 activate distinct JAK kinase family members
The erythropoietin (EPO) receptor and the interleukin-2 (IL-2) receptor beta-chain subunit are members of the cytokine receptor… 
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