Janus kinase 1

Known as: JAK1 Protein Tyrosine Kinase, JAK-1 Protein Tyrosine Kinase, JAK1 
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.
National Institutes of Health

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Topic mentions per year

1991-2017
020406019912017

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND Approximately 75% of objective responses to anti-programmed death 1 (PD-1) therapy in patients with melanoma are… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Myelofibrosis is a Philadelphia chromosome–negative myeloproliferative neoplasm associated with cytopenias… (More)
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Highly Cited
2003
Highly Cited
2003
Peroxisome proliferator-activated receptor (PPAR)-gamma agonists are now emerging as therapeutic drugs for various inflammatory… (More)
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Highly Cited
2003
Highly Cited
2003
Curcumin has been strongly implicated as an anti-inflammatory agent, but the precise mechanisms of its action are largely unknown… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The immune response is regulated through a tightly controlled cytokine network. The counteracting balance between… (More)
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2002
2002
The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic… (More)
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Highly Cited
2001
Highly Cited
2001
We show that Janus kinase 2 (JAK2), and more specifically just its intact N-terminal domain, binds to the erythropoietin receptor… (More)
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Highly Cited
2001
Highly Cited
2001
The goal of this study was to determine the role of the Janus tyrosine kinase (JAK)-signal transducers and activators of… (More)
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Highly Cited
1995
Highly Cited
1995
The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and activators of transcription) 1 and 3 are… (More)
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Highly Cited
1993
Highly Cited
1993
We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response… (More)
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