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Janus kinase 1

Known as: JAK1 Protein Tyrosine Kinase, JAK-1 Protein Tyrosine Kinase, JAK1 
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
The Janus kinases (JAKs) are a pivotal family of protein tyrosine kinases (PTKs) that play prominent roles in numerous cytokine… Expand
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Review
2008
Review
2008
The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs… Expand
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Review
2004
Review
2004
SummaryThe Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four… Expand
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Highly Cited
2003
Highly Cited
2003
Curcumin has been strongly implicated as an anti-inflammatory agent, but the precise mechanisms of its action are largely unknown… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The immune response is regulated through a tightly controlled cytokine network. The counteracting balance between… Expand
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Highly Cited
1997
Highly Cited
1997
The proliferation and differentiation of cells of many lineages are regulated by secreted proteins known as cytokines. Cytokines… Expand
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Highly Cited
1997
Highly Cited
1997
Leptin receptors include a long form (OBRl) with 302 cytoplasmic residues that is presumed to mediate most or all of leptins… Expand
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Highly Cited
1997
Highly Cited
1997
Although much is known about the activation, proliferation, and function of CD4+ T cells, little is known about how they survive… Expand
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Highly Cited
1995
Highly Cited
1995
The cytokines interleukin 2 (IL-2) and IL-15 have similar biological effects on T cells and bind common hematopoietin receptor… Expand
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Highly Cited
1991
Highly Cited
1991
The protein-tyrosine kinases (PTKs) are a burgeoning family of proteins, each of which bears a conserved domain of 250 to 300… Expand
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