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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
It is shown that in the CD4+ T-cell lineage of mice AHR expression is restricted to the TH17 cell subset and its ligation results in the production of the TH16 cytokine interleukin (IL)-22, and AHR ligands may represent co-factors in the development of autoimmune diseases. Expand
Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types1
IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanomaExpand
NetPath: a public resource of curated signal transduction pathways
NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. Expand
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
The identification of another gene that also directs the expression of an antigen recognized on most melanomas by CTL clones that are restricted by HLA-A2 is reported, which is unrelated to any known gene. Expand
Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line
It is found that IL-22 induces activation of JAK1 and Tyk2 but not JAK2, as well as phosphorylation of STAT1, STAT3, and STAT5 on tyrosine residues, extending the similarities between IL- 22 and IL-10. Expand
Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.
The cloning of the human IL-TIF cDNA is reported, which shares 79% amino acid identity with mouse IL- TIF and 25% identity withhuman IL-10, suggesting that this cytokine contributes to the inflammatory response in vivo. Expand
Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-91
Experiments concerning the mechanism regulating IL-TIF expression in T cells indicate that IL-9 induction is rapid, does not require protein synthesis, and depends on the activation of the Janus kinase (JAK)-STAT pathway. Expand
IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis1
It is found that CNS-invading encephalitogenic Th17 cells coexpress IL-22 and that IL- 22 is specifically induced by IL-23 in autoimmune-pathogenic CD4+ T cells in a time- and dose-dependent manner. Expand
New insights into the role of cytokines in asthma.
  • J. Renauld
  • Medicine
  • Journal of clinical pathology
  • 1 August 2001
Both experimental and genetic studies point to TH2 cytokines, such as IL-4,IL-13, IL-5, and IL-9, as important targets for therapeutic applications in patients with asthma, and chemokines play a major role in recruiting the mediators of asthmatic inflammation. Expand
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells
It is demonstrated that IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function, and a role of IL- 9 as a regulator of pathogenic versus protective mechanisms of immune responses is highlighted. Expand