JAK3 gene

Known as: Janus kinase 3, tyrosine-protein kinase JAK3, JANUS KINASE, LEUKOCYTE 
This gene plays a role in signal transduction.

Topic mentions per year

Topic mentions per year

1994-2018
024619942018

Papers overview

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2009
2009
OBJECTIVE S100A4 has been shown to be increased in osteoarthritic (OA) cartilage and to stimulate chondrocytes to produce matrix… (More)
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2008
2008
INTRODUCTION CP-690550 is a small molecule inhibitor of Janus kinase 3 (JAK3), a critical enzyme in the signaling pathway of… (More)
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2008
2008
Janus kinase 3 (JAK-3) is a tyrosine kinase that has been shown to participate in the signaling of several cytokines that are… (More)
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2004
2004
We found 10 individuals from 7 unrelated families among 170 severe combined immunodeficiency (SCID) patients who exhibited 9… (More)
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2004
2004
JAK-3 has been shown to play a key role in cytokine signaling via gammac, e.g. IL-2, 4, 7, 9, 15, 21. The current study describes… (More)
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2004
2004
Haemopoietic stem-cell transplantation is a life-saving treatment for severe combined immune deficiency. However, there has been… (More)
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2001
2001
Mutations of the Janus kinase 3 (JAK3) have been previously described to cause an autosomal recessive variant of severe combined… (More)
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2001
2001
Development of T and natural killer (NK) cells is critically dependent on cytokine signaling, and defects in cytokine receptor… (More)
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2000
2000
Janus kinase 3 (JAK3) is an essential component of cytokine receptor signal transduction pathways required for normal lymphocyte… (More)
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Highly Cited
1994
Highly Cited
1994
Protein-tyrosine kinases (PTKs) are critical enzymes for receptor-mediated signaling in lymphocytes. Because natural killer (NK… (More)
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