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Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Expand
STATs: Signal Transducers and Activators of Transcription
- J. Ihle
- Biology, Medicine
- 9 February 1996
Regarding biological functions, it can be anticipated that in the very near future the phenotypes of mice deficient in the remaining STATs will be described and will thus eliminate further speculation, and it would seem less likely as time goes on that additional family members will emerge. Expand
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
All IL-12 functions tested were disrupted, including the induction of IFN-γ, mitogenesis, enhancement of natural killer cytolytic function and Thl differentiation. Expand
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Reconstitution experiments demonstrate that Jak2 is not required for the generation of lymphoid progenitors, their amplification, or functional differentiation, and plays a critical, nonredundant role in the function of a specific group of cytokines receptors. Expand
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
The results support the hypothesis that JAK2 is the kinase that couples EPO binding to tyrosine phosphorylation and mitogenesis. Expand
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.
It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions. Expand
The Stat family in cytokine signaling.
- J. Ihle
- Biology, Medicine
- Current opinion in cell biology
- 1 April 2001
During the past few years studies from several laboratories have utilized gene disruption approaches to define the function of members of the Stat family of transcription factors. The results have… Expand
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
Stat6-l- mice were deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, and immunoglobulin class switching to IgE, indicating the lack of a non-redundant function in normal development. Expand
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
It is demonstrated that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergocell cycle progression or to express genes controlling cell cycle progression. Expand
The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
It is demonstrated that JAB specifically binds to the tyrosine residue (Y1007) in the activation loop of JAK2, whose phosphorylation is required for activation of kinase activity. Expand