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Janus kinase 2

Known as: JAK2 Protein Tyrosine Kinase, Janus Kinase 2 [Chemical/Ingredient], JAK-2 Protein Tyrosine Kinase 
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as… 
National Institutes of Health

Related topics

Related topics

13 relations
In BloodJAK2 geneJAK3 geneProcess of secretion

Narrower (1)

JAK2 protein, human

Broader (1)

Janus kinase

Papers overview

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Highly Cited
2000
Highly Cited
2000
Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone*
Growth hormone (GH)-inducible suppressors of cytokine signaling (SOCS/CIS proteins) inhibit GH receptor (GHR) signaling to STAT5b… 
Highly Cited
1999
Highly Cited
1999
Regulation of Angiotensin II-induced Phosphorylation of STAT3 in Vascular Smooth Muscle Cells*
Ligand binding to the angiotensin II (Ang II) AT1 receptor on vascular smooth muscle cells (VSMCs) activates the Janus-activated… 
Highly Cited
1998
Highly Cited
1998
Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2
We have demonstrated that growth hormone (GH) activates focal adhesion kinase (FAK), and this activation results in the tyrosine… 
Highly Cited
1998
Highly Cited
1998
Definition of the Role of Tyrosine Residues of the Common β Subunit Regulating Multiple Signaling Pathways of Granulocyte-Macrophage Colony-Stimulating Factor Receptor
ABSTRACT Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces various functions, including the proliferation and… 
Highly Cited
1996
Highly Cited
1996
IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
We have recently reported that IL-13R may share a component with IL-4R. Here we report that both IL-4 and IL-13 share signaling… 
Highly Cited
1995
Highly Cited
1995
Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases (*)
Interleukin (IL)-9 stimulates the proliferation of a variety of hematopoietic lineages through its interaction with a receptor of… 
Highly Cited
1995
Highly Cited
1995
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts… 
Highly Cited
1995
Highly Cited
1995
Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha.
Signaling by a wide variety of cytokines, including interferons, interleukins, and growth factors, involves activation of JAK… 
Highly Cited
1994
Highly Cited
1994
Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase.
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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