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Janus kinase 2

Known as: JAK2 Protein Tyrosine Kinase, Janus Kinase 2 [Chemical/Ingredient], JAK-2 Protein Tyrosine Kinase 
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as… 
National Institutes of Health

Related topics

Related topics

13 relations
In BloodJAK2 geneJAK3 geneProcess of secretion

Narrower (1)

JAK2 protein, human

Broader (1)

Janus kinase

Papers overview

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Highly Cited
2005
Highly Cited
2005
Kinase Activation through Dimerization by Human SH2-B
ABSTRACT The isoforms of SH2-B, APS, and Lnk form a family of signaling proteins that have been described as activators… 
Highly Cited
2005
Highly Cited
2005
JAK2 in Myeloproliferative Disorders Is Not Just Another Kinase
Myeloproliferative disorders (MPD) represent a subcategory of hematological malignancies and are characterized by a stem cell… 
Review
2004
Review
2004
Prolactin Mediated Intracellular Signaling in Mammary Epithelial Cells
Prolactin binds to a member of the cytokine receptor superfamily. The cytoplasmic domain of the prolactin receptor (PrlR)4… 
Highly Cited
2003
Highly Cited
2003
Prolactin-Signal Transduction in Neonatal Rat Pancreatic Islets and Interaction with the Insulin-Signaling Pathway
via 
Highly Cited
2000
Highly Cited
2000
Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.
Signal regulatory proteins (SIRPs) are receptor-like transmembrane proteins, the majority of which contain a cytoplasmic proline… 
Highly Cited
1998
Highly Cited
1998
Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2
We have demonstrated that growth hormone (GH) activates focal adhesion kinase (FAK), and this activation results in the tyrosine… 
1997
1997
The IL-4-induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK1 expression in human fibrosarcoma cells.
It has been shown that IL-4 induces the tyrosine phosphorylation of JAK1 and JAK3 in the majority of hemopoietic cell types, and… 
Highly Cited
1996
Highly Cited
1996
Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the…
Granulocyte colony-stimulating factor (G-CSF) induces rapid phosphorylation of JAK kinases as well as activation of the p21ras… 
Review
1996
Review
1996
Signalling pathway of GH.
GH has long been known as a regulator of body growth and metabolism, yet its mechanism of action at the cellular level has been… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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