JAK2 gene

Known as: Janus kinase 2, JTK10, Janus Kinase 2 (A Protein Tyrosine Kinase) Gene 
This gene is involved in erythropoiesis and signal transduction.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2018
0204019912018

Papers overview

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Highly Cited
2011
Highly Cited
2011
Human JAK2 tyrosine kinase mediates signaling through numerous cytokine receptors. The JAK2 JH2 domain functions as a negative… (More)
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Highly Cited
2009
Highly Cited
2009
Genome-wide association studies have identified a number of new disease susceptibility loci that represent haplotypes defined by… (More)
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Highly Cited
2009
Highly Cited
2009
Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological… (More)
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Highly Cited
2008
Highly Cited
2008
An acquired somatic mutation in the JAK2 gene (JAK2-V617F) is present in the majority of patients with myeloproliferative… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders… (More)
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Highly Cited
2005
Highly Cited
2005
Genome-wide single nucleotide polymorphism analysis has revealed large-scale cryptic regions of acquired homozygosity in the form… (More)
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Highly Cited
2001
Highly Cited
2001
Fusion of the TEL gene on 12p13 to the JAK2 tyrosine kinase gene on 9p24 has been found in human leukemia. TEL-mediated… (More)
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Highly Cited
2000
Highly Cited
2000
Comparative genomic hybridization was applied for a comprehensive screening of frequently occurring net gains and losses of… (More)
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Highly Cited
2000
Highly Cited
2000
The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative… (More)
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Highly Cited
1992
Highly Cited
1992
We have isolated cDNA clones encoding a third, widely expressed, member of the JAK family of protein tyrosine kinases (PTKs). The… (More)
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