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JAK2 protein, human

Known as: Janus Kinase 2, JAK-2 protein, human, EC 2.7.1.112 
Tyrosine-protein kinase JAK2 (1132 aa, ~131 kDa) is encoded by the human JAK2 gene. This protein is involved in immunity, tyrosine phosphorylation… 
National Institutes of Health

Related topics

Related topics

26 relations
Adipocytokine Signaling PathwayCell Differentiation processCell ProliferationEnzyme Gene

Broader (1)

Janus kinase 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
JAK-2 V617F mutation increases heparanase procoagulant activity
Summary Patients with polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) are at increased… 
2012
2012
Vascular rejuvenation through the stromal cell-derived factor 1α/CXC chemokine receptor type 4/Janus kinase 2 signalling pathway.
See related article, pp 1225–1231 Aging progressively narrows the functional reserve of several organs and tissues, in… 
2012
2012
Neuromedin U Peptide Activates STAT5 and S6 in a JAK-2 Dependent Manner and Promotes Erythroid Cell Growth in Primary Erythroid Progenitor Cells
2007
2007
Absence of JAK-2V617F point mutations in multiple myeloma
Multiple myeloma (MM) is a terminal differentiated B-cell chronic lymphoproliferative disorder, characterized by the latent… 
2006
2006
MK-0457, a Novel Multikinase Inhibitor, Is Active in Patients with Chronic Myeloid Leukemia (CML) and Acute Lymphocytic Leukemia (ALL) with the T315I BCR-ABL Resistance Mutation and Patients with…
MK-0457 (VX-680) is a small molecule inhibitor of aurora kinases A, B, and C, FLT3, and JAK-2 with nanomolar level broad spectrum… 
2005
2005
Impaired CXCR 4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells From Patients With Coronary Artery Disease
Transplantation of bone marrow cells as well as circulating endothelial progenitor cells (EPC) enhances neovascularization after… 
2005
2005
Endothelial Progenitor Cells From Patients With Coronary Artery Disease Impaired CXCR 4 Signaling Contributes to the Reduced Neovascularization Capacity of
Transplantation of bone marrow cells as well as circulating endothelial progenitor cells (EPC) enhances neovascularization after… 
1999
1999
Heterodimerization of the alpha and beta chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis.
The high-affinity receptor for interleukin-3 (IL-3) is a complex of the IL-3-binding subunit (alpha(IL-3)) and a larger beta… 
1998
1998
Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor.
Insulin and insulin-like growth factor-1 (IGF-1) treatment of cells overexpressing the insulin receptor or the IGF-1 receptor… 
1996
1996
Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction.
Xu, Xiaowei, and William E. Sonntag. Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by… 
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