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Untangling the ErbB signalling network
When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death,Expand
EGF–ERBB signalling: towards the systems level
It is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Expand
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
This study identifies Cbl proteins as components of the ubiquitin ligation machinery and implies that they similarly suppress many other signaling pathways. Expand
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals closeExpand
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.
An endosomal sorting machinery capable of controlling the fate, and, hence, signaling potency, of growth factor receptors is revealed. Expand
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.
  • Y. Yarden
  • Biology, Medicine
  • European journal of cancer
  • 1 September 2001
Analysis of the multiple processes that modulate EGFR signal transduction has revealed new therapeutic opportunities and elucidated mechanisms contributing to the efficacy of existing anticancer treatments. Expand
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.
The observed superior ability of ErbB-2 to form heterodimers, in conjunction with its uniquely high basal tyrosine kinase activity, may explain why Erb B-2 overexpression is associated with poor prognosis. Expand
Feedback regulation of EGFR signalling: decision making by early and delayed loops
Recent studies show that the collection of feedback regulatory loops can perform computational tasks — such as decoding ligand specificity, transforming graded input signals into a digital output and regulating response kinetics. Expand
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation
It is concluded that LRIG1 evolved in mammals as a feedback negative attenuator of signaling by receptor tyrosine kinases by upregulation ofLRIG1 transcript and protein upon EGF stimulation, and physical association of the encoded protein with the four EGFR orthologs of mammals. Expand
A module of negative feedback regulators defines growth factor signaling
This study addresses the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events ofgrowth factor signaling. Expand