T. Hirano

Publications474
h-index120
Citations56,539
Highly Influential Citations1,629
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • T. Kishimoto
  • 976 Publications • 122,374 Citations
  • M. Murakami
  • 237 Publications • 12,361 Citations
  • D. Kamimura
  • 106 Publications • 3,961 Citations
  • M. Hibi
  • 170 Publications • 24,818 Citations
  • Publications
  • Influence
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
TLDR
Interestingly, NF‐IL6 was shown to bind to the regulatory regions for various acute‐phase protein genes and several other cytokine genes such as TNF, IL‐8 and G‐CSF, implying that NF‐ IL6 has a role in regulation not only for the IL‐6 gene but also for several other genes involved in acute‐ phase reaction, inflammation and hemopoiesis.
View on Wiley
Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
TLDR
With IL 6 transgenic mice, deregulation of the IL 6 expression was suggested to be involved in the generation of plasmacytoma/myeloma and mesangium proliferative glomerulonephritis and the findings suggest the presence of a positive regulatory loop in acute‐phase reaction.
View on Wiley
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
TLDR
SOCS3 selectively blocks signaling by IL-6, thereby preventing its ability to inhibit LPS signaling, and is shown to be a key regulator of the divergent action of these two cytokines.
View on Springer
IL-6 signal transduction and its physiological roles: the signal orchestration model.
Interleukin (IL)-6 is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs. In a target cell, IL-6…
View on PubMed
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
TLDR
Since the IL-6/gp130/STAT3 signaling pathway is involved in both B cell growth and differentiation into plasma cells it is likely to play a central role in the generation of plasma cell neoplasias.
View on Springer
A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells.
TLDR
IL‐6 generates both growth‐enhancing signals and growth arrest‐ and differentiation‐inducing signals at the same time, suggesting Stat3 may be a key molecule which determines the cellular decision from cell growth to differentiation in M1 cells.
View on Wiley
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.
View on PubMed
COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome
View on Elsevier
Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
TLDR
Identification of key components of the HuC promoter has led to the establishment of a stable zebrafish transgenic line (HuC-GFP) in which GFP is expressed specifically in neurons.
View on PubMed
Zinc is a novel intracellular second messenger
TLDR
The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling.
View PDF
...
...