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A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
Interestingly, NF‐IL6 was shown to bind to the regulatory regions for various acute‐phase protein genes and several other cytokine genes such as TNF, IL‐8 and G‐CSF, implying that NF‐ IL6 has a role in regulation not only for the IL‐6 gene but also for several other genes involved in acute‐ phase reaction, inflammation and hemopoiesis.
Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
- S. Akira, T. Hirano, T. Taga, T. Kishimoto
- Biology, MedicineFASEB journal : official publication of the…
- 1 August 1990
With IL 6 transgenic mice, deregulation of the IL 6 expression was suggested to be involved in the generation of plasmacytoma/myeloma and mesangium proliferative glomerulonephritis and the findings suggest the presence of a positive regulatory loop in acute‐phase reaction.
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
SOCS3 selectively blocks signaling by IL-6, thereby preventing its ability to inhibit LPS signaling, and is shown to be a key regulator of the divergent action of these two cytokines.
IL-6 signal transduction and its physiological roles: the signal orchestration model.
Interleukin (IL)-6 is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs. In a target cell, IL-6…
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
Since the IL-6/gp130/STAT3 signaling pathway is involved in both B cell growth and differentiation into plasma cells it is likely to play a central role in the generation of plasma cell neoplasias.
A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells.
IL‐6 generates both growth‐enhancing signals and growth arrest‐ and differentiation‐inducing signals at the same time, suggesting Stat3 may be a key molecule which determines the cellular decision from cell growth to differentiation in M1 cells.
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.
COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome
Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
Identification of key components of the HuC promoter has led to the establishment of a stable zebrafish transgenic line (HuC-GFP) in which GFP is expressed specifically in neurons.
Zinc is a novel intracellular second messenger
The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling.