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TOPBP1 Gene

Known as: KIAA0259, TOP2BP1, DNA TOPOISOMERASE II-BINDING PROTEIN 1 
This gene is involved in DNA replication and apoptosis regulation.
National Institutes of Health

Related topics

Related topics

3 relations
DNA RepairDNA ReplicationDNA topoisomerase II binding protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.
2015
2015
Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding*
Background: Rad9 C-tail interacts with various checkpoint factors. Results: Intramolecular folding of C-tail in 9-1-1 interfered… 
2014
2014
Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and… 
2013
2013
NBS1 directly activates ATR independently of MRE11 and TOPBP1
NBS1 plays unique and essential roles in ATM activation in response to DNA double‐strand breaks. We found that CHK1… 
2011
2011
Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination.
2007
2007
Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we… 
2007
2007
The DNA topoisomerase IIβ binding protein 1 (TopBP1) interacts with poly (ADP‐ribose) polymerase (PARP‐1)
We investigated the physical association of the DNA topoisomerase IIβ binding protein 1 (TopBP1), involved in DNA replication and… 
2006
2006
Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair
Dpb11 is required for the loading of DNA polymerases α and ɛ on to DNA in chromosomal DNA replication and interacts with the DNA… 
Highly Cited
2005
Highly Cited
2005
Human TopBP1 Ensures Genome Integrity during Normal S Phase
ABSTRACT Cell cycle checkpoints are essential for maintaining genomic integrity. Human topoisomerase II binding protein 1 (TopBP1… 
2005
2005
Identification of TopBP1 as a c-Abl-interacting Protein and a Repressor for c-Abl Expression*
Expression of BCR-ABL is the leading cause of chronic myelogenous leukemia. In chronic myelogenous leukemia cells, c-Abl… 
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