TOPBP1 Gene

Known as: KIAA0259, TOP2BP1, DNA TOPOISOMERASE II-BINDING PROTEIN 1 
This gene is involved in DNA replication and apoptosis regulation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0102019972017

Papers overview

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Highly Cited
2011
Highly Cited
2011
The DNA damage response (DDR) is brought about by a protein kinase cascade that orchestrates DNA repair through transcriptional… (More)
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Highly Cited
2010
Highly Cited
2010
Human TopBP1 plays a critical role in the control of DNA replication checkpoint. In this study, we report a specific interaction… (More)
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Highly Cited
2010
Highly Cited
2010
TopBP1 has important roles in both DNA replication and checkpoint regulation in vertebrates. We have identified a protein called… (More)
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Highly Cited
2007
Highly Cited
2007
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin… (More)
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Highly Cited
2007
Highly Cited
2007
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA… (More)
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Highly Cited
2006
Highly Cited
2006
ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control… (More)
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Highly Cited
2006
Highly Cited
2006
TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to genotoxic stress… (More)
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Highly Cited
2006
Highly Cited
2006
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage… (More)
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2004
2004
Mammalian TopBP1 is a BRCT domain-containing protein whose function in mitotic cells is linked to replication and DNA damage… (More)
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Highly Cited
2001
Highly Cited
2001
Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae… (More)
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