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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The ATR checkpoint transmits DNA damage signals through the ATR–Chk1 kinase cascade. However, whether post-translational… 
2012
2012
The RecQL4 helicase is involved in the maintenance of genome integrity and DNA replication. Mutations in the human RecQL4 gene… 
2010
2010
We have used the Xenopus laevis egg extract system to study the roles of vertebrate Dna2 in DNA replication and double-strand… 
Highly Cited
2010
Highly Cited
2010
The diverse roles of TopBP1 in DNA replication and checkpoint signaling are associated with the scaffolding ability of TopBP1 to… 
2009
2009
TopBP1, acting in concert with DNA containing bulky base lesions, stimulates ATR kinase activity under physiologically relevant… 
Highly Cited
2008
Highly Cited
2008
The DNA damage response kinase ATR is an essential regulator of genome integrity. TopBP1 functions as a general activator of ATR… 
Highly Cited
2008
Highly Cited
2008
In this issue of Genes & Development, Mordes and colleagues (pp. 1478-1489) reveal intriguing mechanistic insights into… 
2007
2007
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we… 
2004
2004
MCM10 and TopBP1 function in the initiation of DNA replication, by regulating the chromatin binding of the DNA polymerase… 
Highly Cited
2003
Highly Cited
2003
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1…