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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years… Expand
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Highly Cited
2008
Highly Cited
2008
The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses… Expand
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Highly Cited
2007
Highly Cited
2007
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin… Expand
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Highly Cited
2007
Highly Cited
2007
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA… Expand
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Highly Cited
2006
Highly Cited
2006
ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to… Expand
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Highly Cited
2006
Highly Cited
2006
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… Expand
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Highly Cited
2004
Highly Cited
2004
TopBP1 (DNA topoisomerase IIbeta binding protein I) contains multiple BRCT domains and is involved in replication and the DNA… Expand
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Highly Cited
2002
Highly Cited
2002
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The… Expand
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Highly Cited
2002
Highly Cited
2002
The Myc oncoprotein represses initiator-dependent transcription through the POZ domain transcription factor Miz-1. We now show… Expand
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