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DNA topoisomerase II binding protein
Known as:
KIAA0259
, TopBP1
, DNA Topoisomerase 2-Binding Protein 1
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DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and…
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National Institutes of Health
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Related topics
Related topics
8 relations
BRCT Domain
Cell Nucleus
DNA Repair
DNA Repair Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase
Miiko Sokka
,
Dennis Koalick
,
P. Hemmerich
,
J. Syväoja
,
H. Pospiech
International Journal of Molecular Sciences
2018
Corpus ID: 51982721
The mammalian DNA replication program is controlled at two phases, the licensing of potential origins of DNA replication in early…
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2013
2013
NBS1 directly activates ATR independently of MRE11 and TOPBP1
Masahiko Kobayashi
,
N. Hayashi
,
M. Takata
,
Ken‐ichi Yamamoto
Genes to Cells
2013
Corpus ID: 43032576
NBS1 plays unique and essential roles in ATM activation in response to DNA double‐strand breaks. We found that CHK1…
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2011
2011
Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.
Ziyan Yuan
,
Eric A. Kumar
,
+4 authors
A. Natarajan
ACS Medicinal Chemistry Letters
2011
Corpus ID: 22434516
Breast cancer gene 1 carboxy terminus (BRCT) domains are found in a number of proteins that are important for DNA damage response…
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2011
2011
Prognostic implications of the DNA damage response pathway in glioblastoma.
H. Seol
,
H. Yoo
,
+10 authors
D. Nam
Oncology Report
2011
Corpus ID: 11958422
Genomic instability and resistance to genotoxic therapies for glioblastoma (GBM) suggest aberrant DNA damage response (DDR…
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2009
2009
Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress
Daniël O. Warmerdam
,
R. Freire
,
R. Kanaar
,
V. Smits
Cell Cycle
2009
Corpus ID: 37806102
The Rad9/Rad1/Hus1 complex functions to facilitate the ATR-mediated phosphorylation of several substrates that control the…
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2009
2009
Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1
C. Leung
,
E. Kellogg
,
Anja Kuhnert
,
F. Hänel
,
D. Baker
,
J. Glover
Protein Science
2009
Corpus ID: 26947519
Topoisomerase IIβ binding protein 1 (TopBP1) is a major player in the DNA damage response and interacts with a number of protein…
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2007
2007
Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*
Yesu Jeon
,
Kyung Yong Lee
,
M. Ko
,
Yong Sun Lee
,
Sukhyun Kang
,
D. Hwang
Journal of Biological Chemistry
2007
Corpus ID: 981038
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we…
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2007
2007
The DNA topoisomerase IIβ binding protein 1 (TopBP1) interacts with poly (ADP‐ribose) polymerase (PARP‐1)
Yvonne Wollmann
,
U. Schmidt
,
G. Wieland
,
P. Zipfel
,
H. Saluz
,
F. Hänel
Journal of Cellular Biochemistry
2007
Corpus ID: 22968440
We investigated the physical association of the DNA topoisomerase IIβ binding protein 1 (TopBP1), involved in DNA replication and…
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2006
2006
Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)
K. Reini
2006
Corpus ID: 85896970
Genetic information is stored in the base sequence of DNA. As DNA is often damaged by radiation or reactive chemicals, cells have…
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2005
2005
Identification of TopBP1 as a c-Abl-interacting Protein and a Repressor for c-Abl Expression*
L. Zeng
,
Yuanyu Hu
,
Baojie Li
Journal of Biological Chemistry
2005
Corpus ID: 12567344
Expression of BCR-ABL is the leading cause of chronic myelogenous leukemia. In chronic myelogenous leukemia cells, c-Abl…
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