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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of… 
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Highly Cited
2008
Highly Cited
2008
The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses… 
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Highly Cited
2007
Highly Cited
2007
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin… 
Highly Cited
2007
Highly Cited
2007
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA… 
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Highly Cited
2006
Highly Cited
2006
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Highly Cited
2006
Highly Cited
2006
ABSTRACT TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to… 
Highly Cited
2002
Highly Cited
2002
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The… 
Highly Cited
2002
Highly Cited
2002
The Myc oncoprotein represses initiator-dependent transcription through the POZ domain transcription factor Miz-1. We now show… 
Highly Cited
2001
Highly Cited
2001
Topoisomerase IIβ-binding protein (TopBP1), a human protein with eight BRCT domains, is similar toSaccharomyces cerevisiae Dpb11…