DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… (More)
National Institutes of Health

Related topics

Related topics

8 relations
BRCT DomainCell NucleusDNA RepairDNA Repair Gene
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication
TopBP1 has important roles in both DNA replication and checkpoint regulation in vertebrates. We have identified a protein called… (More)
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Highly Cited
2008
Highly Cited
2008
Dpb11 activates the Mec1-Ddc2 complex.
The Saccharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an essential regulator of… (More)
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Highly Cited
2006
Highly Cited
2006
TopBP1 Activates the ATR-ATRIP Complex
ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control… (More)
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Highly Cited
2006
Highly Cited
2006
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… (More)
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2003
2003
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1… (More)
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Highly Cited
2003
Highly Cited
2003
Regulation of E2F1 by BRCT domain-containing protein TopBP1.
The E2F transcription factor integrates cellular signals and coordinates cell cycle progression. Our prior studies demonstrated… (More)
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2002
2002
Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The… (More)
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Highly Cited
2002
Highly Cited
2002
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.
BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair and/or DNA damage-signaling… (More)
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Highly Cited
2001
Highly Cited
2001
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.
Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae… (More)
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Highly Cited
1997
Highly Cited
1997
A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.
A two-hybrid system was used to isolate factors that interact with the C-terminal region of DNA topoisomerase IIbeta. A positive… (More)
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