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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… 
National Institutes of Health

Related topics

Related topics

8 relations
BRCT DomainCell NucleusDNA RepairDNA Repair Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase
The mammalian DNA replication program is controlled at two phases, the licensing of potential origins of DNA replication in early… 
2013
2013
NBS1 directly activates ATR independently of MRE11 and TOPBP1
NBS1 plays unique and essential roles in ATM activation in response to DNA double‐strand breaks. We found that CHK1… 
2011
2011
Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.
Breast cancer gene 1 carboxy terminus (BRCT) domains are found in a number of proteins that are important for DNA damage response… 
2011
2011
Prognostic implications of the DNA damage response pathway in glioblastoma.
Genomic instability and resistance to genotoxic therapies for glioblastoma (GBM) suggest aberrant DNA damage response (DDR… 
2009
2009
Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress
The Rad9/Rad1/Hus1 complex functions to facilitate the ATR-mediated phosphorylation of several substrates that control the… 
2009
2009
Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1
Topoisomerase IIβ binding protein 1 (TopBP1) is a major player in the DNA damage response and interacts with a number of protein… 
2007
2007
Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we… 
2007
2007
The DNA topoisomerase IIβ binding protein 1 (TopBP1) interacts with poly (ADP‐ribose) polymerase (PARP‐1)
We investigated the physical association of the DNA topoisomerase IIβ binding protein 1 (TopBP1), involved in DNA replication and… 
2006
2006
Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)
Genetic information is stored in the base sequence of DNA. As DNA is often damaged by radiation or reactive chemicals, cells have… 
2005
2005
Identification of TopBP1 as a c-Abl-interacting Protein and a Repressor for c-Abl Expression*
Expression of BCR-ABL is the leading cause of chronic myelogenous leukemia. In chronic myelogenous leukemia cells, c-Abl… 
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