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DNA topoisomerase II binding protein
Known as:
KIAA0259
, TopBP1
, DNA Topoisomerase 2-Binding Protein 1
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DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and…
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National Institutes of Health
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Related topics
Related topics
8 relations
BRCT Domain
Cell Nucleus
DNA Repair
DNA Repair Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
A. N. Blackford
,
S. Jackson
Molecules and Cells
2017
Corpus ID: 206997898
Highly Cited
2016
Highly Cited
2016
ETAA1 acts at stalled replication forks to maintain genome integrity
Thomas E. Bass
,
Jessica W Luzwick
,
+7 authors
D. Cortez
Nature Cell Biology
2016
Corpus ID: 22888928
The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of…
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Highly Cited
2008
Highly Cited
2008
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Daniel A. Mordes
,
G. Glick
,
R. Zhao
,
D. Cortez
Genes & Development
2008
Corpus ID: 5535978
The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses…
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Highly Cited
2007
Highly Cited
2007
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
S. Delacroix
,
J. Wagner
,
Masahiko Kobayashi
,
Ken‐ichi Yamamoto
,
L. Karnitz
Genes & Development
2007
Corpus ID: 30271480
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin…
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Highly Cited
2007
Highly Cited
2007
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*
Joon Lee
,
A. Kumagai
,
W. Dunphy
Journal of Biological Chemistry
2007
Corpus ID: 14513178
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA…
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Highly Cited
2006
Highly Cited
2006
TopBP1 Activates the ATR-ATRIP Complex
A. Kumagai
,
Joon Lee
,
H. Yoo
,
W. Dunphy
Cell
2006
Corpus ID: 18019463
Highly Cited
2006
Highly Cited
2006
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
Dong Zhang
,
K. Zaugg
,
T. Mak
,
S. Elledge
Cell
2006
Corpus ID: 15997453
Highly Cited
2003
Highly Cited
2003
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
K. Yamane
,
Junjie Chen
,
T. Kinsella
Cancer Research
2003
Corpus ID: 41332983
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1…
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Highly Cited
2002
Highly Cited
2002
Cooperation of HECT-domain Ubiquitin Ligase hHYD and DNA Topoisomerase II-binding Protein for DNA Damage Response*
Yoshiomi Honda
,
M. Tojo
,
+5 authors
M. Nakao
Journal of Biological Chemistry
2002
Corpus ID: 11111184
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The…
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Highly Cited
2002
Highly Cited
2002
Negative regulation of the mammalian UV response by Myc through association with Miz-1.
Steffi Herold
,
M. Wanzel
,
+7 authors
M. Eilers
Molecules and Cells
2002
Corpus ID: 29640235
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