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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… 
National Institutes of Health

Related topics

Related topics

8 relations
BRCT DomainCell NucleusDNA RepairDNA Repair Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
Highly Cited
2016
Highly Cited
2016
ETAA1 acts at stalled replication forks to maintain genome integrity
The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of… 
Highly Cited
2008
Highly Cited
2008
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses… 
Highly Cited
2007
Highly Cited
2007
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin… 
Highly Cited
2007
Highly Cited
2007
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA… 
Highly Cited
2006
Highly Cited
2006
TopBP1 Activates the ATR-ATRIP Complex
Highly Cited
2006
Highly Cited
2006
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
Highly Cited
2003
Highly Cited
2003
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1… 
Highly Cited
2002
Highly Cited
2002
Cooperation of HECT-domain Ubiquitin Ligase hHYD and DNA Topoisomerase II-binding Protein for DNA Damage Response*
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The… 
Highly Cited
2002
Highly Cited
2002
Negative regulation of the mammalian UV response by Myc through association with Miz-1.
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