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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… 
National Institutes of Health

Related topics

Related topics

8 relations
BRCT DomainCell NucleusDNA RepairDNA Repair Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
Abstract The contribution of nucleoli to the cellular stress response has been discussed for over a decade. Stress-induced… 
2014
2014
Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and… 
2012
2012
The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif
The RecQL4 helicase is involved in the maintenance of genome integrity and DNA replication. Mutations in the human RecQL4 gene… 
2011
2011
THE RAD9-RAD1-HUS1 (9.1.1) COMPLEX INTERACTS WITH WRN AND IS CRUCIAL TO REGULATE ITS RESPONSE TO REPLICATION FORK STALLING
The WRN protein belongs to the RecQ family of DNA helicases and is implicated in replication fork restart, but how its function… 
2011
2011
Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.
Breast cancer gene 1 carboxy terminus (BRCT) domains are found in a number of proteins that are important for DNA damage response… 
2010
2010
Casein kinase 2‐dependent phosphorylation of human Rad9 mediates the interaction between human Rad9‐Hus1‐Rad1 complex and TopBP1
The checkpoint clamp Rad9‐Hus1‐Rad1 (9‐1‐1) is loaded by the Rad17–RFC complex onto chromatin after DNA damage and plays a key… 
2009
2009
Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress
The Rad9/Rad1/Hus1 complex functions to facilitate the ATR-mediated phosphorylation of several substrates that control the… 
2007
2007
Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we… 
2006
2006
Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)
Genetic information is stored in the base sequence of DNA. As DNA is often damaged by radiation or reactive chemicals, cells have… 
Highly Cited
2003
Highly Cited
2003
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1… 
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