DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
TopBP1 has important roles in both DNA replication and checkpoint regulation in vertebrates. We have identified a protein called… (More)
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Highly Cited
2008
Highly Cited
2008
The Saccharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an essential regulator of… (More)
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Highly Cited
2006
Highly Cited
2006
ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control… (More)
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Highly Cited
2006
Highly Cited
2006
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… (More)
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2003
2003
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1… (More)
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Highly Cited
2003
Highly Cited
2003
The E2F transcription factor integrates cellular signals and coordinates cell cycle progression. Our prior studies demonstrated… (More)
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2002
2002
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The… (More)
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Highly Cited
2002
Highly Cited
2002
BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair and/or DNA damage-signaling… (More)
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Highly Cited
2001
Highly Cited
2001
Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae… (More)
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Highly Cited
1997
Highly Cited
1997
A two-hybrid system was used to isolate factors that interact with the C-terminal region of DNA topoisomerase IIbeta. A positive… (More)
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