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DNA topoisomerase II binding protein
Known as:
KIAA0259
, TopBP1
, DNA Topoisomerase 2-Binding Protein 1
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DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and…
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National Institutes of Health
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Related topics
Related topics
8 relations
BRCT Domain
Cell Nucleus
DNA Repair
DNA Repair Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
A. K. Velichko
,
N. V. Petrova
,
+6 authors
O. Kantidze
Nucleic Acids Research
2019
Corpus ID: 205256645
Abstract The contribution of nucleoli to the cellular stress response has been discussed for over a decade. Stress-induced…
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2014
2014
Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.
Zhiping Li
,
Ke Chen
,
+9 authors
R. Pestell
Cancer Research
2014
Corpus ID: 13888371
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and…
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2012
2012
The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif
O. Ohlenschläger
,
Anja Kuhnert
,
+9 authors
H. Pospiech
Nucleic Acids Research
2012
Corpus ID: 7489236
The RecQL4 helicase is involved in the maintenance of genome integrity and DNA replication. Mutations in the human RecQL4 gene…
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2011
2011
THE RAD9-RAD1-HUS1 (9.1.1) COMPLEX INTERACTS WITH WRN AND IS CRUCIAL TO REGULATE ITS RESPONSE TO REPLICATION FORK STALLING
P. Pichierri
,
S. Nicolai
,
Luca Cignolo
,
M. Bignami
,
A. Franchitto
Oncogene
2011
Corpus ID: 18097012
The WRN protein belongs to the RecQ family of DNA helicases and is implicated in replication fork restart, but how its function…
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2011
2011
Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.
Ziyan Yuan
,
Eric A. Kumar
,
+4 authors
A. Natarajan
ACS Medicinal Chemistry Letters
2011
Corpus ID: 22434516
Breast cancer gene 1 carboxy terminus (BRCT) domains are found in a number of proteins that are important for DNA damage response…
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2010
2010
Casein kinase 2‐dependent phosphorylation of human Rad9 mediates the interaction between human Rad9‐Hus1‐Rad1 complex and TopBP1
Yukimasa Takeishi
,
E. Ohashi
,
Kaori Ogawa
,
H. Masai
,
C. Obuse
,
T. Tsurimoto
Genes to Cells
2010
Corpus ID: 19698217
The checkpoint clamp Rad9‐Hus1‐Rad1 (9‐1‐1) is loaded by the Rad17–RFC complex onto chromatin after DNA damage and plays a key…
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2009
2009
Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress
Daniël O. Warmerdam
,
R. Freire
,
R. Kanaar
,
V. Smits
Cell Cycle
2009
Corpus ID: 37806102
The Rad9/Rad1/Hus1 complex functions to facilitate the ATR-mediated phosphorylation of several substrates that control the…
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2007
2007
Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*
Yesu Jeon
,
Kyung Yong Lee
,
M. Ko
,
Yong Sun Lee
,
Sukhyun Kang
,
D. Hwang
Journal of Biological Chemistry
2007
Corpus ID: 981038
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we…
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2006
2006
Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)
K. Reini
2006
Corpus ID: 85896970
Genetic information is stored in the base sequence of DNA. As DNA is often damaged by radiation or reactive chemicals, cells have…
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Highly Cited
2003
Highly Cited
2003
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
K. Yamane
,
Junjie Chen
,
T. Kinsella
Cancer Research
2003
Corpus ID: 41332983
Cell cycle checkpoints play a central role in genomic stability. The human DNA topoisomerase II-binding protein 1 (TopBP1…
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