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DNA topoisomerase II binding protein

Known as: KIAA0259, TopBP1, DNA Topoisomerase 2-Binding Protein 1 
DNA topoisomerase 2-binding protein 1 (1522 aa, ~171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and… Expand
National Institutes of Health

Related topics

Related topics

8 relations
BRCT DomainCell NucleusDNA RepairDNA Repair Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years… Expand
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Highly Cited
2008
Highly Cited
2008
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses… Expand
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Highly Cited
2007
Highly Cited
2007
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin… Expand
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Highly Cited
2007
Highly Cited
2007
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA… Expand
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Highly Cited
2006
Highly Cited
2006
TopBP1 Activates the ATR-ATRIP Complex
ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control… Expand
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Highly Cited
2006
Highly Cited
2006
Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation
ABSTRACT TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to… Expand
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Highly Cited
2006
Highly Cited
2006
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… Expand
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Highly Cited
2004
Highly Cited
2004
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.
TopBP1 (DNA topoisomerase IIbeta binding protein I) contains multiple BRCT domains and is involved in replication and the DNA… Expand
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Highly Cited
2002
Highly Cited
2002
Cooperation of HECT-domain Ubiquitin Ligase hHYD and DNA Topoisomerase II-binding Protein for DNA Damage Response*
Ubiquitin ligases define the substrate specificity of protein ubiquitination and subsequent proteosomal degradation. The… Expand
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Highly Cited
2002
Highly Cited
2002
Negative regulation of the mammalian UV response by Myc through association with Miz-1.
The Myc oncoprotein represses initiator-dependent transcription through the POZ domain transcription factor Miz-1. We now show… Expand
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