Skip to search formSkip to main contentSkip to account menu

BRCT Domain

Known as: Breast Cancer Carboxy-Terminal Domain 
BRCT domain was first identified in C-terminal domain of breast cancer associated protein and was found in many proteins that regulate the cellular… 
National Institutes of Health

Related topics

Related topics

11 relations
BRCA1 Associated RING Domain 1 ProteinBRCA1 protein, humanDNA topoisomerase II binding proteinLIG4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis
Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis… 
2012
2012
Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study
BackgroundBRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but… 
2011
2011
Functional Evolution of BRCT Domains from Binding DNA to Protein
The BRCT domain (BRCA1 C-terminal domain) is an important signaling and protein targeting motif in the DNA damage response system… 
2011
2011
Solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae reveals a novel fold.
2008
2008
A novel domain of BRCA1 interacts with p53 in breast cancer cells.
2006
2006
Solution NMR structure of the BRCT domain from Thermus thermophilus DNA ligase : Surface features suggest novel intermolecular interactions
About half of all familial cases of human breast and ovarian cancers are caused by mutations in the BRCA1 and BRCA2 genes. The… 
Highly Cited
2005
Highly Cited
2005
The Tandem BRCT Domains of Ect2 Are Required for Both Negative and Positive Regulation of Ect2 in Cytokinesis*
Epithelial cell transforming protein 2 (Ect2) is a guanine nucleotide exchange factor (GEF) for Rho GTPases, molecular switches… 
2001
2001
Solution structure and backbone dynamics of the human DNA ligase IIIalpha BRCT domain.
BRCT (BRCA1 carboxyl terminus) domains are found in a number of DNA repair enzymes and cell cycle regulators and are believed to… 
Highly Cited
2000
Highly Cited
2000
Mutation of a BRCT domain selectively disrupts DNA single-strand break repair in noncycling Chinese hamster ovary cells.
The DNA single-strand break repair protein XRCC1 contains a BRCT domain that binds and stabilizes intracellular DNA ligase III… 
2000
2000
A Functional Comparison of BRCA1 C-terminal Domains in Transcription Activation and Chromatin Remodeling*
The BRCA1 C-terminal (BRCT) domain is present in a number of proteins that are involved in various aspects of chromosomal events… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)