LIG4 protein, human

Known as: Polydeoxyribonucleotide Synthase, Sealase protein, human, DNA Joinase 
DNA ligase 4 (911 aa, ~104 kDa) is encoded by the human LIG4 gene. This protein plays a role in non-homologous end joining during both DNA repair and… (More)
National Institutes of Health

Papers overview

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2016
2016
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt… (More)
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Highly Cited
2014
Highly Cited
2014
Breakpoint junctions of the chromosomal translocations that occur in human cancers display hallmarks of nonhomologous end-joining… (More)
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Highly Cited
2013
Highly Cited
2013
Improved methods for engineering sequence-specific nucleases, including zinc finger nucleases (ZFNs) and TAL effector nucleases… (More)
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2011
Highly Cited
2011
Mammalian cells have three ATP-dependent DNA ligases, which are required for DNA replication and repair. Homologues of ligase I… (More)
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2010
2010
DNA ligase IV (LIG4) is an essential component of the nonhomologous end-joining (NHEJ) repair pathway and plays a key role in V(D… (More)
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2008
2008
Although the role of environmental risk factors in the etiology of gliomas remains to be elucidated, accumulative epidemiological… (More)
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Highly Cited
2007
Highly Cited
2007
Immunoglobulin variable region exons are assembled in developing B cells by V(D)J recombination. Once mature, these cells undergo… (More)
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Highly Cited
2007
Highly Cited
2007
In vitro antioxidant and antimutagenic activities of two polyphenols isolated from the fruits of Pistacia lentiscus was assessed… (More)
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2002
Highly Cited
2002
We performed genetic association studies in a population-based breast cancer case-control study analysing polymorphisms in genes… (More)
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Highly Cited
1997
Highly Cited
1997
DNA ligases catalyse the joining of single and double-strand DNA breaks, which is an essential final step in DNA replication… (More)
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