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LIG4 protein, human

Known as: Polydeoxyribonucleotide Synthase, Sealase protein, human, DNA Joinase 
DNA ligase 4 (911 aa, ~104 kDa) is encoded by the human LIG4 gene. This protein plays a role in non-homologous end joining during both DNA repair and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Improved methods for engineering sequence-specific nucleases, including zinc finger nucleases (ZFNs) and TAL effector nucleases… Expand
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Highly Cited
2013
Highly Cited
2013
Ligase IV, but not its catalytic function, is required for DNA-PK–dependent end synapsis during nonhomologous end joining. 
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Highly Cited
2011
Highly Cited
2011
Mammalian cells have three ATP-dependent DNA ligases, which are required for DNA replication and repair. Homologues of ligase I… Expand
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Highly Cited
2010
Highly Cited
2010
The classical nonhomologous end-joining (C-NHEJ) DNA double-strand break (DSB) repair pathway employs the Ku70/80 complex (Ku… Expand
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Highly Cited
2009
Highly Cited
2009
Using zinc-finger nucleases (ZFNs) to cleave the chromosomal target, we have achieved high frequencies of gene targeting in the… Expand
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Highly Cited
2007
Highly Cited
2007
Immunoglobulin variable region exons are assembled in developing B cells by V(D)J recombination. Once mature, these cells undergo… Expand
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Highly Cited
2007
Highly Cited
2007
In vitro antioxidant and antimutagenic activities of two polyphenols isolated from the fruits of Pistacia lentiscus was assessed… Expand
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Highly Cited
2002
Highly Cited
2002
We performed genetic association studies in a population-based breast cancer case-control study analysing polymorphisms in genes… Expand
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Highly Cited
1998
Highly Cited
1998
Saccharomyces cerevisiae DNA ligase IV (LIG4) has been shown previously to be involved in non‐homologous DNA end joining and… Expand
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Highly Cited
1997
Highly Cited
1997
DNA ligases catalyse the joining of single and double‐strand DNA breaks, which is an essential final step in DNA replication… Expand
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