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LIG4 protein, human

Known as: Polydeoxyribonucleotide Synthase, Sealase protein, human, DNA Joinase 
DNA ligase 4 (911 aa, ~104 kDa) is encoded by the human LIG4 gene. This protein plays a role in non-homologous end joining during both DNA repair and… 
National Institutes of Health

Related topics

Related topics

20 relations
BRCT DomainCell NucleusDNA LigasesDNA ligase

Broader (3)

DNA Repair EnzymesDNA ligase IVPolynucleotide Ligases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Different profiles of the mRNA levels of DNA repair genes in MCF-7 and SH-SY5Y cells after treatment with combination of cisplatin, 50-Hz electromagnetic field and bleomycin.
2015
2015
Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.
2013
2013
C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.
2013
2013
Saccharomyces cerevisiae LIF 1 : a function involved in DNA double-strand break repair related to mammalian XRCC 4
Saccharomyces cerevisiae DNA ligase IV (LIG4) has been shown previously to be involved in non-homologous DNA end joining and… 
2012
2012
A high-throughput scintillation proximity-based assay for human DNA ligase IV.
Ionizing radiation (IR) and certain chemotherapeutic drugs are designed to generate cytotoxic DNA double-strand breaks (DSBs) in… 
Review
2012
Review
2012
Lack of association between LIG4 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.
OBJECTIVE Non-homologous end joining (NHEJ) is one of the pathways of repair of DNA double-strand breaks. A number of genes… 
2009
2009
DNA ligase IV as a new molecular target for temozolomide.
Highly Cited
2007
Highly Cited
2007
Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4.
2001
2001
Phenotypic Analysis and Virulence of Candida albicans LIG4 Mutants
ABSTRACT In previous studies, we reported the isolation and preliminary characterization of a DNA ligase-encoding gene of Candida… 
1978
1978
T4 polynucleotide ligase catalyzed joining of short synthetic DNA duplexes at base-paired ends.
The self-complementary octanucleotide dT-A-G-T-A-C-T-A has been synthesized and its sequence confirmed by two-dimensional… 
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