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BRCA1 Associated RING Domain 1 Protein

Known as: BARD-1, BRCA1-Associated RING Domain 1, BRCA1 Associated RING Domain Protein 1 
BRCA1-associated RING domain protein 1 (777 aa, ~87 kDa) is encoded by the human BARD1 gene. This protein plays a role in cell cycle progression, DNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase with BARD1. BRCA1-associated protein 1… Expand
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Highly Cited
2009
Highly Cited
2009
We conducted a SNP-based genome-wide association study (GWAS) focused on the high-risk subset of neuroblastoma. As our previous… Expand
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Highly Cited
2004
Highly Cited
2004
The N-terminus of the BRCA1 protein bears a RING finger domain that functions as an E3 ubiquitin ligase in vitro where it is able… Expand
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Highly Cited
2002
Highly Cited
2002
Loss of the tumour suppressor BRCA1 results in profound chromosomal instability. The fundamental defect underlying this… Expand
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Highly Cited
2002
Highly Cited
2002
The RING finger of BRCA1 confers ubiquitin ligase activity that is markedly enhanced when complexed with another RING-containing… Expand
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Highly Cited
2001
Highly Cited
2001
BRCA1-BARD1 constitutes a heterodimeric RING finger complex associated through its N-terminal regions. Here we demonstrate that… Expand
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Highly Cited
2001
Highly Cited
2001
The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the… Expand
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Highly Cited
2001
Highly Cited
2001
Cancer-predisposing missense mutations in the RING domain of BRCA1 primarily target Zn2+-liganding residues. Here we report on… Expand
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Highly Cited
1999
Highly Cited
1999
The proto-oncoprotein Bcl-3 is a member of the IκB family and is present predominantly in the nucleus. To gain insight into… Expand
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Highly Cited
1997
Highly Cited
1997
  • Y. Jin, X. L. Xu, +4 authors R. Baer
  • Proceedings of the National Academy of Sciences…
  • 1997
  • Corpus ID: 7767893
Germ-line mutations of the BRCA1 gene predispose women to early-onset breast and ovarian cancer by compromising the gene's… Expand
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