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MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.
- Penka S. Petrova, A. Raibekas, J. Commissiong
- BiologyJournal of molecular neuroscience : MN
- 1 April 2003
The selective, neuroprotective effect of MANF for dopaminergic neurons suggests that it may be indicated for the treatment of Parkinson's disease.
Role for the p53 homologue p73 in E2F-1-induced apoptosis
It is concluded that activation of p73 provides a means for E2F-1 to induce death in the absence of p53, and the transcription of the p53 homologue p73 is induced.
Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer
- S. Denison, Gwen Callahan, N. Becker, L. Phillips, David I. Smith
- BiologyGenes, chromosomes & cancer
- 1 September 2003
Characterization of FRA6E (6q26), the third most frequently observed common fragile site (CFS) in the human population, determined that aphidicolin‐induced instability at FRA6E extends over a very…
Mutations in CHEK2 associated with prostate cancer risk.
The data suggest that mutations in CHEK2 may contribute to prostate cancer risk and that the DNA-damage-signaling pathway may play an important role in the development of prostate cancer.
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
These mutations cause premature degradation of mutant proteins, reduced methyltransferase activity and impaired heterochromatin binding during the G2 cell cycle phase leading to global hypomethylation and site-specific hypermethylation.
Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
Data indicate that besides the approximately 20% of HCCs and 80% of HBs with β-catenin mutations contributing to hepatocarcinogenesis, AXIN1 and AXIN2 mutations appear to be important in an additional 10%.
Loss of HSulf-1 Up-regulates Heparin-binding Growth Factor Signaling in Cancer*
Observations provide evidence that HSulf-1 modulates signaling by heparin-binding growth factors, and HS sulfur-1 down-regulation represents a novel mechanism by which cancer cells can enhance growth factor signaling.
Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon
Studies at a molecular level show distinct expression profiles of different histologies of ovarian cancer and support the long-held belief that histotypes of ovarian cancers come to resemble normal fallopian tube, endometrial, and colonic epithelium.
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling (vol 26, pg 146, 2000)
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
Observations raise the possibility of HtrA1 as a candidate tumor suppressor involved in promoting serine-protease-mediated cell death and that downregulation of HTRA1 in ovarian cancer may contribute to malignant phenotype.