David I. Smith

Sort by:

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

Haojie Huang, Kevin Regan, +4 authors Donald J. Tindall
Proceedings of the National Academy of Sciences…
2005

Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis. Loss of function of these factors due… (More)

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

Jinping Lai, Jeremey Chien, +7 authors Vijayalakshmi Shridhar
The Journal of biological chemistry
2003

Emerging data suggest that signaling by heparin-binding growth factors is influenced by the sulfation state of N-acetylglucosamine residues of heparan sulfate proteoglycans (HSPGs). Here we report… (More)

Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing.

Andrew L. Feldman, A. Latif Dogan, +8 authors George Vasmatzis
Blood
2011

The genetics of peripheral T-cell lymphomas are poorly understood. The most well-characterized abnormalities are translocations involving ALK, occurring in approximately half of anaplastic large cell… (More)

3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer

Yan W. Asmann, Eric W. Klee, +8 authors Jean-Pierre A. Kocher
BMC Genomics
2009

Massive parallel sequencing has the potential to replace microarrays as the method for transcriptome profiling. Currently there are two protocols: full-length RNA sequencing (RNA-SEQ) and 3'-tag… (More)

Role for the p53 homologue p73 in E2F-1-induced apoptosis

Meredith S Irwin, Maria Del Carmen Marin, +8 authors William G Kaelin
Nature
2000

The transcription factor E2F-1 induces both cell-cycle progression and, in certain settings, apoptosis. E2F-1 uses both p53-dependent and p53-independent pathways to kill cells. The p53-dependent… (More)

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

Wanguo Liu, Xiangyang Dong, +10 authors Stephen N. Thibodeau
Nature Genetics
2000

In a recent Letter, we used the TIGR Human Gene Index (HGI, release 5.0) to estimate that the human genome contained 120,000 genes. The estimate of the number of genes, Ngenome, relied on five… (More)

Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Ken Taniguchi, Lewis R. Roberts, +9 authors Wanguo Liu
Oncogene
2002

Activation of Wnt signaling through β-catenin mutations contributes to the development of hepatocellular carcinoma (HCC) and hepatoblastoma (HB). To explore the contribution of additional Wnt pathway… (More)

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

Christopher Jon Klein, Maria-Victoria Botuyan, +20 authors David I. Smith
Nature Genetics
2011

DNA methyltransferase 1 (DNMT1) is crucial for maintenance of methylation, gene regulation and chromatin stability. DNA mismatch repair, cell cycle regulation in post-mitotic neurons and neurogenesis… (More)

Mutations in CHEK2 associated with prostate cancer risk.

Xiangyang Dong, Liang Wang, +15 authors Wanguo Liu
American journal of human genetics
2003

The DNA-damage-signaling pathway has been implicated in all human cancers. However, the genetic defects and the mechanisms of this pathway in prostate carcinogenesis remain poorly understood. In this… (More)

Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations.

Wendy F Liu, David I. Smith, K J Rechtzigel, Stephen N. Thibodeau, C. David James
Nucleic acids research
1998

Denaturing high performance liquid chromatography (DHPLC) has been described recently as a method for screening DNA samples for single nucleotide polymorphisms and inherited mutations. Thirty-eight… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences