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TOP1 gene

Known as: Topoisomerase (DNA) I Gene, TOPOISOMERASE, DNA, I, topoisomerase (DNA) I 
This gene is involved in the regulation of both DNA topology and transcription.
National Institutes of Health

Related topics

Related topics

4 relations
DNA Topoisomerases, Type IDNA Topology RegulationTOP1 protein, humanTranscriptional Regulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Top1 and Top2 promote replication fork arrest at a programmed pause site
This Outlook discusses Shyian et al.’s finding showing that topoisomerases play an unexpected role in the regulation of… 
2018
2018
Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
2015
2015
Dimerization and thiol sensitivity of the salicylic acid binding thimet oligopeptidases TOP1 and TOP2 define their functions in redox-sensitive cellular pathways
A long-term goal in plant research is to understand how plants integrate signals from multiple environmental stressors. The… 
2012
2012
Development and Validation of an Immunoassay for Quantification of Topoisomerase I in Solid Tumor Tissues
Background Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT… 
2006
2006
Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes
Topoisomerase I (Top1) is a ubiquitous enzyme that removes DNA supercoiling generated during transcription and replication. Top1… 
Highly Cited
2003
Highly Cited
2003
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-one (ARC-111, topovale) is a… 
2002
2002
Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment‐related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15)
The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias… 
2000
2000
Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1
Abstract The Saccharomyces cerevisiae gene SGS1 encodes a DNA helicase that shows homology to the Escherichia coli protein RecQ… 
1997
1997
A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning.
The terbenzimidazoles are a class of synthetic ligands that poison the human topoisomerase I (TOP1) enzyme and promote cancer… 
Highly Cited
1990
Highly Cited
1990
HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay… 
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