TOP1 gene

Known as: Topoisomerase (DNA) I Gene, TOPOISOMERASE, DNA, I, topoisomerase (DNA) I 
This gene is involved in the regulation of both DNA topology and transcription.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Topoisomerase I (Top1) releases torsional stress during DNA replication and transcription and is inhibited by camptothecin and… (More)
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2010
2010
Because topoisomerase 1 (TOP1) is critical for the relaxation of DNA supercoils and because it is the target for the anticancer… (More)
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Highly Cited
2010
Highly Cited
2010
Pre-rRNA transcription by RNA Polymerase I (Pol I) is very robust on active rDNA repeats. Loss of yeast Topoisomerase I (Top1… (More)
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Highly Cited
2009
Highly Cited
2009
Topoisomerase I (Top1) is a key enzyme in functioning at the interface between DNA replication, transcription and mRNA maturation… (More)
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Review
2009
Review
2009
DNA topoisomerases I and II (Top1 and Top2) are established molecular targets of anticancer drugs.1-5 Mammalian somatic cells… (More)
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Highly Cited
2007
Highly Cited
2007
DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are… (More)
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Highly Cited
2002
Highly Cited
2002
When a replication fork collides with a DNA topoisomerase I (Top1) cleavage complex, the covalently bound enzyme must be removed… (More)
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2002
2002
The locations of the origin recognition complex (ORC) in mammalian genomes have been elusive. We have therefore analyzed the DNA… (More)
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1990
1990
The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay… (More)
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Highly Cited
1988
Highly Cited
1988
We have found that mitotic recombination within the S. cerevisiae rDNA cluster (200 tandemly repeated 9.1 kb units) is strongly… (More)
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