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Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes.
TLDR
The nucleotide sequence of the smallest chromosome, chr1, has a 257-kilobase region that is densely packed with 79 protein-coding genes, and predicts a total of approximately 9,800 genes in Leishmania, of which 40% may encode unknown proteins. Expand
The Arabidopsis oligopeptidases TOP1 and TOP2 are salicylic acid targets that modulate SA-mediated signaling and the immune response.
TLDR
It is demonstrated that thimet oligopeptidases (TOPs) constitute a class of SA-binding enzymes and that TOP1 and TOP2 mediate SA-dependent signaling and are necessary for the immune response to avirulent pathogens. Expand
Proteome-Wide Analysis of Cysteine Reactivity during Effector-Triggered Immunity1[OPEN]
TLDR
Describing the ETI redoxomes in Arabidopsis (Arabidopsis thaliana) wild-type Col-0 and top1top2 mutant plants using a differential alkylation-based enrichment technique coupled with label-free mass spectrometry-based quantification significantly expands the repertoire of oxidation-sensitive plant proteins and can guide future mechanistic studies. Expand
Cell cycle–dependent association of polo kinase Cdc5 with CENP-A contributes to faithful chromosome segregation in budding yeast
TLDR
It is reported that evolutionarily conserved CEN histone H3 variant, Cse4 (CENP-A in humans), is a substrate of Cdc5, and that the cell cycle–regulated association of Cse3 with Cse5 is required for cell growth, and a role for CDC5-mediated CSE4 phosphorylation in faithful chromosome segregation is defined. Expand
Dimerization and thiol sensitivity of the salicylic acid binding thimet oligopeptidases TOP1 and TOP2 define their functions in redox-sensitive cellular pathways
TLDR
This work indicates that TOP1 and TOP2 mediate plant responses to oxidative stress through spatially separated pathways and positions proteolysis in a network for plant response to diverse stressors. Expand
Targeting Hsp-90 Related Disease Entities for Therapeutic Development
TLDR
The available inhibitors and those in development are explored, the relevant disease processes are discussed, and the pitfalls and promises of targeting HSP-90 for therapeutic intervention are examined. Expand