All Fields
Computer Science
Medicine
FAQ
Contact
Sign in
DNA Topoisomerases, Type I
Known as:
DNA Untwisting Protein
, DNA Nicking-Closing Protein
, DNA Untwisting Enzyme
Â
(More)
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and…Â
(More)
National Institutes of Health
Topic mentions per year
Topic mentions per year
1975-2017
0
100
200
300
1975
2017
Related topics
Related topics
19 relations
DNA Replication
DNA topoisomerase I activity
In Blood
Process of secretion
(More)
Broader (2)
DNA Topoisomerases
Isomerase
Narrower (4)
DNA reverse gyrase
DNA topoisomerase III
TOP1 protein, human
parE Protein
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
DNA Topoisomerases, Type I
physiological aspects
DNA Replication
irinotecan
chemical synthesis
Isomerase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Antitumour drugs impede DNA uncoiling by topoisomerase I.
Daniel A Koster
,
Komaraiah Palle
,
Elisa S M Bot
,
M A Bjornsti
,
Nynke H Dekker
Nature
2007
Increasing the ability of chemotherapeutic drugs to kill cancer cells is often hampered by a limited understanding of their…Â
(More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy
Hiroshi Takashima
,
Cornelius F. Boerkoel
,
+9 authors
James R Lupski
Nature Genetics
2002
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase I–DNA complexes and is essential for preventing the…Â
(More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
E. J. Morris
,
Herbert M Geller
The Journal of cell biology
1996
Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme DNA topoisomerase-I (topo-I…Â
(More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
Sophie Catherine Gangloff
,
J P Mcdonald
,
Christine Bendixen
,
Larry O. Arthur
,
Richard Rothstein
Molecular and cellular biology
1994
We have previously shown that cells mutant for TOP3, a gene encoding a prokaryotic-like type I topoisomerase in Saccharomyces…Â
(More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
Weston Nelson
,
Michael B. Kastan
Molecular and cellular biology
1994
The tumor suppressor protein p53 serves as a critical regulator of a G1 cell cycle checkpoint and of apoptosis following exposure…Â
(More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.
Y H Hsiang
,
Michelle G. Lihou
,
L. F. Liu
Cancer research
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of…Â
(More)
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.
Y H Hsiang
,
L. F. Liu
Cancer research
1988
Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor of nucleic acid synthesis and a…Â
(More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
DNA topoisomerase II is required at the time of mitosis in yeast.
Carole T Holm
,
T. Goto
,
J. C. Wang
,
David Botstein
Cell
1985
We have constructed five new temperature-sensitive DNA topoisomerase II mutations and have analyzed their physiological…Â
(More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Y H Hsiang
,
Richard Hertzberg
,
Sidney M Hecht
,
L. F. Liu
The Journal of biological chemistry
1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand…Â
(More)
Is this relevant?
Highly Cited
1984
Highly Cited
1984
DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.
Steven J Dinardo
,
Katarzyna Voelkel
,
R Weylin Sternglanz
Proceedings of the National Academy of Sciences…
1984
A temperature-sensitive DNA topoisomerase II mutant of the yeast Saccharomyces cerevisiae has been identified. Genetic analysis…Â
(More)
Is this relevant?