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DNA Topoisomerases, Type I

Known as: DNA Untwisting Protein, DNA Nicking-Closing Protein, DNA Untwisting Enzyme 
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Although yoga and meditation have been used for stress reduction with reported improvement in inflammation, little is… Expand
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Highly Cited
2004
Highly Cited
2004
DNA Topoisomerase IIalpha (topoIIalpha) is a DNA decatenating enzyme, abundant constituent of mammalian mitotic chromosomes, and… Expand
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Review
1998
Review
1998
The major established cause of acute myeloid leukemia (AML) in the young is cancer chemotherapy. There are two forms of treatment… Expand
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Highly Cited
1989
Highly Cited
1989
Yeast Saccharomyces cerevisiae strains that are permeable to the antitumor alkaloid camptothecin are killed by the drug if they… Expand
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Highly Cited
1987
Highly Cited
1987
DNA topoisomerase I was purified to near homogeneity from a clonal line of human lymphoblastic leukemia cells, RPMI 8402, that is… Expand
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Highly Cited
1985
Highly Cited
1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand… Expand
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Highly Cited
1985
Highly Cited
1985
Rabbit antibodies specific to yeast DNA topoisomerase I were used in immunological screening of a Saccharomyces cerevisiae… Expand
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Highly Cited
1983
Highly Cited
1983
Using the P4 unknotting assay, DNA topoisomerase II has been purified from several mammalian cells. Similar to prokaryotic DNA… Expand
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Highly Cited
1983
Highly Cited
1983
The purified type II DNA topoisomerase from the embryos of Drosophila melanogaster exists in its native form as a dimer of 170… Expand
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