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DNA Topoisomerases, Type I

Known as: DNA Untwisting Protein, DNA Nicking-Closing Protein, DNA Untwisting Enzyme 
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and… 
National Institutes of Health

Related topics

Related topics

21 relations
DNA ReplicationDNA topoisomerase I activityIn BloodProcess of secretion
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Broader (2)

DNA TopoisomerasesIsomerase

Narrower (8)

DNA reverse gyraseDNA topoisomerase IIIDNA topoisomerase VNikB protein, Salmonella typhimurium
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Genome Organization Drives Chromosome Fragility
Highly Cited
2011
Highly Cited
2011
Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I
DNA topoisomerases control DNA topology by breaking and rejoining DNA strands via covalent complexes with cleaved DNA substrate… 
Review
1998
Review
1998
Secondary leukemias induced by topoisomerase-targeted drugs.
  • C. Felix
  • Biochimica et biophysica acta
  • 1998
  • Corpus ID: 23938812
Highly Cited
1989
Highly Cited
1989
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
Yeast Saccharomyces cerevisiae strains that are permeable to the antitumor alkaloid camptothecin are killed by the drug if they… 
Highly Cited
1988
Highly Cited
1988
Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants
Highly Cited
1987
Highly Cited
1987
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.
DNA topoisomerase I was purified to near homogeneity from a clonal line of human lymphoblastic leukemia cells, RPMI 8402, that is… 
Highly Cited
1985
Highly Cited
1985
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Highly Cited
1983
Highly Cited
1983
Cleavage of DNA by mammalian DNA topoisomerase II.
Highly Cited
1983
Highly Cited
1983
Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.
The purified type II DNA topoisomerase from the embryos of Drosophila melanogaster exists in its native form as a dimer of 170… 
Highly Cited
1975
Highly Cited
1975
Determination of the number of superhelical turns in simian virus 40 DNA by gel electrophoresis.
  • W. Keller
  • Proceedings of the National Academy of Sciences…
  • 1975
  • Corpus ID: 39037445
Closed-circular, superhelical DNA from simian virus 40 (SV40 DNA I) was treated with an excess of DNA-relaxing enzyme in the… 
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