DNA Topoisomerases, Type I

Known as: DNA Untwisting Protein, DNA Nicking-Closing Protein, DNA Untwisting Enzyme 
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
010020030019752017

Papers overview

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Highly Cited
2007
Highly Cited
2007
Increasing the ability of chemotherapeutic drugs to kill cancer cells is often hampered by a limited understanding of their… (More)
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Highly Cited
2002
Highly Cited
2002
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase I–DNA complexes and is essential for preventing the… (More)
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Highly Cited
1996
Highly Cited
1996
Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme DNA topoisomerase-I (topo-I… (More)
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Highly Cited
1994
Highly Cited
1994
We have previously shown that cells mutant for TOP3, a gene encoding a prokaryotic-like type I topoisomerase in Saccharomyces… (More)
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Highly Cited
1994
Highly Cited
1994
The tumor suppressor protein p53 serves as a critical regulator of a G1 cell cycle checkpoint and of apoptosis following exposure… (More)
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Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… (More)
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Highly Cited
1988
Highly Cited
1988
Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor of nucleic acid synthesis and a… (More)
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Highly Cited
1985
Highly Cited
1985
We have constructed five new temperature-sensitive DNA topoisomerase II mutations and have analyzed their physiological… (More)
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Highly Cited
1985
Highly Cited
1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand… (More)
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Highly Cited
1984
Highly Cited
1984
A temperature-sensitive DNA topoisomerase II mutant of the yeast Saccharomyces cerevisiae has been identified. Genetic analysis… (More)
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