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DNA Topoisomerases, Type I

Known as: DNA Untwisting Protein, DNA Nicking-Closing Protein, DNA Untwisting Enzyme 
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and… Expand
National Institutes of Health

Related topics

Related topics

21 relations
DNA ReplicationDNA topoisomerase I activityIn BloodProcess of secretion
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Broader (2)

DNA TopoisomerasesIsomerase

Narrower (8)

DNA reverse gyraseDNA topoisomerase IIIDNA topoisomerase VNikB protein, Salmonella typhimurium
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.
Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer… Expand
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Highly Cited
2013
Highly Cited
2013
Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial
BACKGROUND Although yoga and meditation have been used for stress reduction with reported improvement in inflammation, little is… Expand
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Highly Cited
2004
Highly Cited
2004
Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line.
DNA Topoisomerase IIalpha (topoIIalpha) is a DNA decatenating enzyme, abundant constituent of mammalian mitotic chromosomes, and… Expand
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Review
1998
Review
1998
Secondary leukemias induced by topoisomerase-targeted drugs.
The major established cause of acute myeloid leukemia (AML) in the young is cancer chemotherapy. There are two forms of treatment… Expand
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Highly Cited
1989
Highly Cited
1989
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
Yeast Saccharomyces cerevisiae strains that are permeable to the antitumor alkaloid camptothecin are killed by the drug if they… Expand
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Highly Cited
1987
Highly Cited
1987
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.
DNA topoisomerase I was purified to near homogeneity from a clonal line of human lymphoblastic leukemia cells, RPMI 8402, that is… Expand
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Highly Cited
1985
Highly Cited
1985
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand… Expand
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Highly Cited
1985
Highly Cited
1985
Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.
Rabbit antibodies specific to yeast DNA topoisomerase I were used in immunological screening of a Saccharomyces cerevisiae… Expand
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Highly Cited
1983
Highly Cited
1983
Cleavage of DNA by mammalian DNA topoisomerase II.
Using the P4 unknotting assay, DNA topoisomerase II has been purified from several mammalian cells. Similar to prokaryotic DNA… Expand
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Highly Cited
1983
Highly Cited
1983
Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.
The purified type II DNA topoisomerase from the embryos of Drosophila melanogaster exists in its native form as a dimer of 170… Expand
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