TOP1 protein, human

Known as: EC 5.99.1.2, Topo I, DNA Topoisomerase I 
DNA topoisomerase I (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation of DNA topology.
National Institutes of Health

Papers overview

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2015
2015
Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress… (More)
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Highly Cited
2014
Highly Cited
2014
Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced… (More)
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Review
2012
Review
2012
An ortholog of activation-induced cytidine deaminase (AID) was, evolutionarily, the first enzyme to generate acquired immune… (More)
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2011
2011
High levels of transcription in Saccharomyces cerevisiae are associated with increased genetic instability, which has been linked… (More)
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Highly Cited
2009
Highly Cited
2009
Systemic sclerosis (SSc) is a connective tissue disorder of great clinical heterogeneity. Its pathophysiology remains unclear… (More)
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Highly Cited
2005
Highly Cited
2005
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl… (More)
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2001
2001
Topoisomerase 1 (top1) inhibitors are proving useful against a range of refractory tumors, and there is considerable interest in… (More)
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1995
1995
The development of camptothecin-like compounds as inhibitors of topoisomerase I for the treatment of resistant tumors has… (More)
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Highly Cited
1994
Highly Cited
1994
The effect of lowering intracellular glutathione (GSH) concentrations on the toxicity of alkylating agents, and RNA synthesis… (More)
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1990
1990
The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay… (More)
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