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Two genetic pathways, t(1;10) and amplification of 3p11–12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions
TLDR
The identified genetic aberrations were not confined to MIFS; an identical t(1;10) was also found in a case of HFT and the amplicon in 3p was seen in an IMFH and the consequences of these alterations for gene expression were assessed. Expand
Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.
TLDR
The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS. Expand
Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).
TLDR
It is shown here that a novel t(10;16)(q22;p13) in a childhood AML M5a leads to a MORF-CBP chimera, and their exact role in the leukemogenic process remains to be elucidated. Expand
The chimeric FUS/CREB3l2 gene is specific for low‐grade fibromyxoid sarcoma
TLDR
Results indicated that FUS/CREB3L2 is specifically associated with LGFMS and that RT‐PCR or FISH analysis may be useful for the differential diagnosis. Expand
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
TLDR
It is shown that a t(7;16)(q33;p11) in two cases of low grade fibromyxoid sarcoma fuses the FUS gene to BBF2H7, a previously uncharacterized gene that is homologous to the Drosophila Bbf-2 gene. Expand
Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
TLDR
The genomic structure of FUS shows extensive similarities with that of EWS, but the exon/intron structures differ in the 5' parts, and overall FUS is smaller than EWS. Expand
Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
TLDR
Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant F US/CREb3L1 fusion. Expand
ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity
TLDR
Tumors with ZC3H7B–BCOR fusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology. Expand
POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands
TLDR
The fusion of EWSR1 and POU5F1 in two types of epithelial tumours is reported, showing that although the chimera is capable of significant transcriptional activation, it may in fact convey a negative regulatory effect on target genes. Expand
Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses
TLDR
The molecular genetic characteristics of CCS from 10 patients are described and topoisomerase I consensus sequences were found close to the junctions, suggesting that this enzyme may participate in the genesis of the EWS/ATF1 fusion. Expand
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