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TLR8 gene

Known as: Toll-Like Receptor 8 Gene, TLR8, CD288 
This gene plays a role in receptor signaling and in immune responses.
National Institutes of Health

Related topics

Related topics

6 relations
Immune responseLigand BindingReceptor SignalingTLR8 protein, human
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Papers overview

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2017
2017
A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a…
Background A phase 2, randomized, placebo-controlled trial was conducted in women with recurrent epithelial ovarian carcinoma to… Expand
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2015
2015
Enrichment assessment of multiple virtual screening strategies for Toll-like receptor 8 agonists based on a maximal unbiased benchmarking data set.
Toll-like receptor 8 agonists, which activate adaptive immune responses by inducing robust production of T-helper 1-polarizing… Expand
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2014
2014
Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells.
Nucleic acid-sensing TLRs are involved in both antimicrobial immune responses and autoimmune inflammation. TLR8 is… Expand
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2014
2014
Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.
Females of child-bearing age are more resistant to infectious disease and have an increased risk of systemic lupus erythematosus… Expand
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2011
2011
TLR7 and TLR8 Gene Variations and Susceptibility to Hepatitis C Virus Infection
Toll-like receptors (TLRs) play pivotal roles in the innate immune system and control inflammatory responses and adaptive… Expand
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2009
2009
Polymorphisms of TLR7 and TLR8 associated with risk of asthma and asthma-related phenotypes in a southeastern Chinese Han population
Abstract Objective To evaluate the effects of polymorphisms in TLR7 and TLR8 (as potential candidate genes) on asthma risk and… Expand
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Highly Cited
2008
Highly Cited
2008
A functional toll-like receptor 8 variant is associated with HIV disease restriction.
BACKGROUND Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR8 has been found to… Expand
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2008
2008
Innate immune response gene expression profiles characterize primary antiphospholipid syndrome
Primary antiphospholipid syndrome (PAPS) is a systemic autoimmune disorder characterized by thromboembolic episodes and pregnant… Expand
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2007
2007
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats.
Toll-like receptors (TLR) detect conserved molecular patterns expressed by pathogens. Detection of the "molecular signature" for… Expand
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2007
2007
Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy.
BACKGROUND In recent reports, human toll-like receptor (TLR) 8 mediates the antiviral response by recognizing single-stranded RNA… Expand
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