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TLR8 gene

Known as: Toll-Like Receptor 8 Gene, TLR8, CD288 
This gene plays a role in receptor signaling and in immune responses.
National Institutes of Health

Related topics

Related topics

6 relations
Immune responseLigand BindingReceptor SignalingTLR8 protein, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a…
Background A phase 2, randomized, placebo-controlled trial was conducted in women with recurrent epithelial ovarian carcinoma to… Expand
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2016
2016
Molecular cloning and functional characterization of murine toll-like receptor 8
Toll-like receptors (TLRs) are a large family of germ-line encoded pattern recognition receptors (PRRs) that recognize pathogen… Expand
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2015
2015
Enrichment Assessment of Multiple Virtual Screening Strategies for Toll‐Like Receptor 8 Agonists Based on a Maximal Unbiased Benchmarking Data Set
Toll‐like receptor 8 agonists, which activate adaptive immune responses by inducing robust production of T‐helper 1‐polarizing… Expand
2014
2014
Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells
Nucleic acid–sensing TLRs are involved in both antimicrobial immune responses and autoimmune inflammation. TLR8 is… Expand
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2014
2014
Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.
Females of child-bearing age are more resistant to infectious disease and have an increased risk of systemic lupus erythematosus… Expand
2011
2011
TLR7 and TLR8 Gene Variations and Susceptibility to Hepatitis C Virus Infection
Toll-like receptors (TLRs) play pivotal roles in the innate immune system and control inflammatory responses and adaptive… Expand
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Highly Cited
2008
Highly Cited
2008
A functional toll-like receptor 8 variant is associated with HIV disease restriction.
BACKGROUND Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR8 has been found to… Expand
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2008
2008
Innate immune response gene expression profiles characterize primary antiphospholipid syndrome
Primary antiphospholipid syndrome (PAPS) is a systemic autoimmune disorder characterized by thromboembolic episodes and pregnant… Expand
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Highly Cited
2007
Highly Cited
2007
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats.
Toll-like receptors (TLR) detect conserved molecular patterns expressed by pathogens. Detection of the "molecular signature" for… Expand
2007
2007
Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy.
BACKGROUND In recent reports, human toll-like receptor (TLR) 8 mediates the antiviral response by recognizing single-stranded RNA… Expand
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