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Syk kinase

Known as: Syk Kinase [Chemical/Ingredient], SYK Tyrosine Kinase, Spleen Tyrosine Kinase 
An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL… 
National Institutes of Health

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In BloodProcess of secretionSYK geneantagonists & inhibitors

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SYK protein, human

Papers overview

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Review
2019
Review
2019
Syk: a new target for attenuation of Helicobacter pylori-induced gastric mucosal inflammatory responses
The magnitude of gastric mucosal inflammatory response to H. pylori relies primarily on the extent of its key endotoxin, LPS… 
2018
2018
Helicobacter pylori LPS-induced gastric mucosal spleen tyrosine kinase (Syk) recruitment to TLR4 and activation occurs with the involvement of protein kinase Cδ
Spleen tyrosine kinase (Syk) has emerged recently as a major effector of proinflammatory genes expression induced by LPS-elicited… 
2016
2016
Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells
LPS consists of a relatively conserved region of lipid A and core oligosaccharide and a highly variable region of O-antigen… 
Review
2014
Review
2014
Angioimmunoblastic T-cell lymphoma in Taiwan shows a frequent gain of ITK gene.
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma (PTCL) of follicular helper T-cell origin… 
2012
2012
Phosphorylated Syk expression is enhanced in Nasu‐Hakola disease brains
Nasu‐Hakola disease (NHD) is a rare autosomal recessive disorder, characterized by progressive presenile dementia and formation… 
2012
2012
Novel insights into the innate immune response to non‐tuberculous Mycobacteria
Inflammasomes are cytosolic protein complexes that regulate the activity of caspase-1, and thereby trigger the caspase-1… 
2009
2009
ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain.
Spleen tyrosine kinase (Syk) is activated when its tandem SH2 domain (tSH2) binds to a diphosphorylated ITAM motif of e.g. the… 
2008
2008
Differential Dephosphorylation of the FcRγ Immunoreceptor Tyrosine-based Activation Motif Tyrosines with Dissimilar Potential for Activating Syk*
The cell surface-expressed γ chain of the high affinity receptor for IgE (FcϵRI) can be phosphorylated on two tyrosine residues… 
Highly Cited
1998
Highly Cited
1998
Syk activation is required for spreading and H2O2 release in adherent human neutrophils.
Chemoattractant-stimulated polymorphonuclear leukocytes (PMNs) that are adherent to extracellular matrix proteins exhibit a… 
1997
1997
Direct T Cell Activation by Chimeric Single Chain Fv-Syk Promotes Syk-Cbl Association and Cbl Phosphorylation*
The protein tyrosine kinase Syk is activated upon engagement of immune recognition receptors. We have focused on the… 
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